{"created":"2023-05-15T16:32:43.990898+00:00","id":4692,"links":{},"metadata":{"_buckets":{"deposit":"acb73211-2846-464b-92db-522ad6f3400e"},"_deposit":{"created_by":2,"id":"4692","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4692"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004692","sets":["8:9"]},"author_link":["19007","19010","19006","19009","19013","19004","19012","19005","19014","19015","19011","19008"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"2034","bibliographicPageStart":"2027","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of the present study was to elucidate the associations between the expression of the vascular endothelial growth factor-C (VEGF-C)/VEGF receptor-3 (VEGFR-3) axis and lymphangiogenesis, regional lymph node metastasis and clinicopathological factors in oral tongue squamous cell carcinoma (OTSCC) using immunohistochemistry. The expression of VEGF-C, VEGFR-3 and podoplanin was immunohistochemically evaluated in specimens obtained from 65 patients with OTSCC (T1-2, N0) who had undergone radical surgery alone. The associations between the expression of VEGF-C, VEGFR-3 and podoplanin, and lymphangiogenesis, regional lymph node metastasis and clinocopathological factors were determined by immunohistochemical analysis. VEGF-C, VEGFR-3 and combined VEGF-C/VEGFR-3 expression was significantly higher in cases with regional recurrence compared with those without lymph node involvement (P<0.001). As regards lymphangiogenesis, a significant correlation was observed between podoplanin expression and VEGF-C, VEGFR-3 and combined VEGF-C/VEGFR-3 expression (P<0.001). Therefore, lymphangiogenesis in the peritumoral stroma was associated with lymph node metastasis. However, podoplanin expression did not exhibit a significant correlation with the progression of lymph node metastasis. The results of the present study suggest that the VEGF-C/VEGFR-3 axis may be associated with lymph node metastasis through lymphangiogenesis. Determining the VEGF-C/VEGFR-3 expression status may help predict which patients will develop regional recurrence and provide novel targets for therapies to suppress lymph node metastasis in the treatment of OTSCC.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oncology Letters, 10(4), pp.2027-2034; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2015.3565","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Naruse et al. This is an open access article distributed under the terms of a Creative Commons Attribution License."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naruse, Tomofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanamoto, Souichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Shin-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Hidenori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushita, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imayama, Naomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Hisazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Shuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asahina, Izumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umeda, Masahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"OncLet10_2027.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OncLet10_2027.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4692/files/OncLet10_2027.pdf"},"version_id":"854a5450-54ac-4980-9429-0c6bc56387b5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Podoplanin","subitem_subject_scheme":"Other"},{"subitem_subject":"Regional recurrence","subitem_subject_scheme":"Other"},{"subitem_subject":"Tongue cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular endothelial growth factor receptor-3","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular endothelial growth factor-C","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-11"},"publish_date":"2015-09-11","publish_status":"0","recid":"4692","relation_version_is_last":true,"title":["Immunohistochemical study of vascular endothelial growth factor‑C/vascular endothelial growth factor receptor‑3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T22:56:05.163975+00:00"}