{"created":"2023-05-15T16:32:44.705176+00:00","id":4709,"links":{},"metadata":{"_buckets":{"deposit":"d484e55a-34b5-4e71-bf37-413a7d123f5c"},"_deposit":{"created_by":2,"id":"4709","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4709"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004709","sets":["73:74"]},"author_link":["19105","19097","19099","19098","19100","19101","19103","19104","19102"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"854","bibliographicPageStart":"848","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacy and Pharmacology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives The aim of this study was to determine the factor changing the hepatic disposition of a drug during hypothermia using a rat liver perfusion system. Methods The livers of male Wistar rats were perfused at 37, 32 or 28°C in the single-pass mode. Venous outflow dilution patterns and biliary excretion rate patterns of phenolsulfonphthalein (PSP), indocyanine green (ICG) and fluorescein isothiocyanate (FITC)-dextran (FD-4, MW 4400) after the injection of a bolus into the perfused rat liver were analysed based on statistical moment theory. Key findings The first-pass extraction ratio (E h) of PSP was significantly decreased at 32 and 28°C compared with 37°C. The biliary recovery of PSP and its conjugate was decreased and the biliary excretion was kept at a high concentration and was prolonged by low perfusion temperatures. ICG was almost extracted by a single-pass through the liver even at 32 and 28°C. The biliary recovery of ICG was significantly decreased at low temperature. Although the distribution volume of FD-4 as a vascular reference was not changed by perfusion temperature, the E h of FD-4 was decreased at 28°C although not markedly. Conclusion The change in hepatic disposition of a drug at low perfusion temperatures differed according to disposition processes under hypothermia.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Pharmacy and Pharmacology, 64(6), pp.848-854; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Press"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.2042-7158.2012.01478.x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2012 Royal Pharmaceutical Society"},{"subitem_rights":"This is the peer reviewed version of the following article: Journal of Pharmacy and Pharmacology, 64(6), pp.848-854; 2012, which has been published in final form at http://dx.doi.org/10.1111/j.2042-7158.2012.01478.x This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00223573","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyamoto, Hirotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyake, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirata, Haruna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohwaki, Yuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fumoto, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Junzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Koyo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JPP64_848.pdf","filesize":[{"value":"379.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JPP64_848.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4709/files/JPP64_848.pdf"},"version_id":"56a34309-8672-4906-b748-34dd0567efab"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatic disposition","subitem_subject_scheme":"Other"},{"subitem_subject":"indocyanine green","subitem_subject_scheme":"Other"},{"subitem_subject":"liver perfusion","subitem_subject_scheme":"Other"},{"subitem_subject":"phenolsulfonphthalein","subitem_subject_scheme":"Other"},{"subitem_subject":"therapeutic hypothermia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-25"},"publish_date":"2015-09-25","publish_status":"0","recid":"4709","relation_version_is_last":true,"title":["Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:16:55.806258+00:00"}