{"created":"2023-05-15T16:32:44.790777+00:00","id":4711,"links":{},"metadata":{"_buckets":{"deposit":"a40f5bdd-6684-4ca8-876b-d9b959d21001"},"_deposit":{"created_by":2,"id":"4711","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4711"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004711","sets":["73:74"]},"author_link":["19122","19123","19117","19119","19118","19121","19120","19116","19124"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"489","bibliographicPageStart":"481","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Biopharmaceutics & Drug Disposition"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of hypothermia on the in vivo pharmacokinetics of midazolam was evaluated, with a focus on altered metabolism in the liver and binding to serum proteins. Rat primary hepatocytes were incubated with midazolam (which is metabolized mainly by CYP3A2) at 37, 32 or 28℃. The Michaelis?Menten constant (Km) and maximum velocity (Vmax) of midazolam were estimated using the Michaelis?Menten equation. The Km of CYP3A2 midazolam remained unchanged, but the Vmax decreased at 28℃. In rats, whose temperature was maintained at 37, 32 or 28℃ by a heat lamp or ice pack, the plasma concentrations of midazolam were higher, whereas those in the brain and liver were unchanged at 28℃. The tissue/plasma concentration ratios were, however, increased significantly. The unbound fraction of midazolam in serum at 28?°C was half that at 37℃. These pharmacokinetic changes associated with hypothermic conditions were due to reductions in CYP3A2 activity and protein binding.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biopharmaceutics & Drug Disposition, 36(7), pp.481-489; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons, Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/bdd.1960","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 John Wiley & Sons, Ltd."},{"subitem_rights":"This is the peer reviewed version of the following article: Biopharmaceutics & Drug Disposition, 36(7), pp.481-489; 2015, which has been published in final form at http://dx.doi.org/10.1002/bdd.1960 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01422782","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyamoto, Hirotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsueda, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moritsuka, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimokawa, Kenta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirata, Haruna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Mikiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fumoto, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Koyo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BDD36_481.pdf","filesize":[{"value":"795.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BDD36_481.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4711/files/BDD36_481.pdf"},"version_id":"c071afbe-6613-49e0-ac5f-82ff9defd768"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"therapeutic hypothermia","subitem_subject_scheme":"Other"},{"subitem_subject":"midazolam","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP3A2","subitem_subject_scheme":"Other"},{"subitem_subject":"protein binding","subitem_subject_scheme":"Other"},{"subitem_subject":"distribution","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-01"},"publish_date":"2016-11-01","publish_status":"0","recid":"4711","relation_version_is_last":true,"title":["Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:16:51.879691+00:00"}