{"created":"2023-05-15T16:32:46.536930+00:00","id":4748,"links":{},"metadata":{"_buckets":{"deposit":"a8ff761f-9a15-41c5-8078-ee5a4f573f12"},"_deposit":{"created_by":2,"id":"4748","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4748"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004748","sets":["73:74"]},"author_link":["19365","19363","19366","19367","19364"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"329","bibliographicPageStart":"320","bibliographicVolumeNumber":"412","bibliographic_titles":[{"bibliographic_title":"Molecular and Cellular Endocrinology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Atherosclerosis is a disease characterized by building up plaques formation and leads to a potentially serious condition in which arteries are clogged by fatty substances such as cholesterol. Increasing evidence suggests that atherosclerosis is accelerated in type 2 diabetes. Recent study reported that high level of alkyl glycerophosphate (AGP) was accumulated in atherosclerotic lesions. The presence of this phospholipid in mildly oxidized low-density lipoprotein (LDL) is likely to be involved in atherogenesis. It has been reported that the activation of peroxisome proliferator-activated receptor gamma plays a key role in developing atherosclerosis. Our previous result indicates that cyclic phosphatidic acid (cPA), one of bioactive lipids, potently suppresses neointima formation by inhibiting the activation of peroxisome proliferator-activated receptor gamma (PPARγ). However, the detailed mechanism is still unclear. In this study, to elucidate the mechanism of the cPA-PPARγ axis in the coronary artery endothelium, especially in patients with type 2 diabetes, we investigated the proliferation, migration, and secretion of VEGF in human coronary artery endothelial cells from diabetes patients (D-HCAECs). AGP induced cell growth and migration; however, cPA suppressed the AGP-elicited growth and migration in D-HCAECs. Moreover, AGP increased VEGF secretion from D-HCAECs, and this event was attenuated by cPA. Taken together, these results suggest that cPA suppresses VEGF-stimulated growth and migration in D-HCAECs. These findings could be important for regulatory roles of PPARγ and VEGF in the vascular processes associated with diabetes and atherosclerosis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Molecular and Cellular Endocrinology, 412, pp.320-329; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.mce.2015.05.021","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Elsevier Ireland Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03037207","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsukahara, Tamotsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukahara, Ryoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haniu, Hisao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Yoshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami-Murofushi, Kimiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MCE412_320.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MCE412_320.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4748/files/MCE412_320.pdf"},"version_id":"726e9769-8398-4b3d-89f7-27b4af53a890"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cyclic phosphatidic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetic human coronary artery endothelial cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Peroxisome proliferator-activated receptor gamma","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-09-06"},"publish_date":"2016-09-06","publish_status":"0","recid":"4748","relation_version_is_last":true,"title":["Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:16:05.889473+00:00"}