@article{oai:nagasaki-u.repo.nii.ac.jp:00004886,
 author = {Takeda, Eiji and Yamanaka-Okumura, Hisami and Taketani, Yutaka and Inagaki, Nobuya and Hosokawa, Masaya and Shide, Kenichiro and Maegawa, Hiroshi and Kondo, Keiko and Kawasaki, Eiji and Shinozaki, Shoko and Fujinaka, Yuichi and Matsubara, Tsukasa and Katayama, Takafumi and Sasaki, Hajime and Kawashima, Akihiro and Aonuma, Hiromitsu},
 issue = {2},
 journal = {Journal of Clinical Biochemistry and Nutrition},
 month = {Sep},
 note = {The isomaltulose based liquid formula (MHN-01), suppresses postprandial plasma glucose and insulin levels in healthy persons and patients with impaired glucose tolerance (IGT) or type 2 diabetes. MHN-01 intake as a part of breakfast also suppresses glucose and insulin levels after lunch, suggesting second meal effect. The objective of this study was to investigate the effects of nutritional counseling and long-term (24 weeks) MHN-01 ingestion on biomarkers of metabolic syndrome. Forty-one subjects with criteria of metabolic syndrome participated in this study composed with the control period (0-12 week) followed by nutritional counseling and the experimental period (12-36 week) followed by 200 kcal (837 kJ) of MHN-01 or dextrin-based standard balanced liquid formula (SBF) loading as a part of breakfast. In 16 of 41 subjects became to out of criteria for liquid formula loading study during control period (unqualified group). In the unqualified group, several biomarkers were improved. In experimental period, serum HbA1c levels significantly increased in SBF group (n = 12) but did not change in MHN-01 group (n = 10). Thus, intake of 837 kJ MHN- 01 as a part of breakfast may be effective for suppression of deteriorating glucose metabolism in metabolic syndrome., Journal of Clinical Biochemistry and Nutrition, 57(2), pp.140-144; 2015},
 pages = {140--144},
 title = {Effect of nutritional counseling and long term isomaltulose based liquid formula (MHN-01) intake on metabolic syndrome},
 volume = {57},
 year = {2015}
}