{"created":"2023-05-15T16:32:54.560868+00:00","id":4936,"links":{},"metadata":{"_buckets":{"deposit":"ec939c22-4334-4cf6-b097-b4004a78284e"},"_deposit":{"created_by":2,"id":"4936","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4936"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004936","sets":["29:30"]},"author_link":["20180","20181","20174","20175","20186","20177","20185","20179","20184","20182","20178","20176","20183"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"16567","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to a delicate balance between self-renewal and multi-lineage differentiation in mES cells. Here, we tested whether known H2A ubiquitin ligases and deubiquitylases are involved in mES cell regulation and discovered that Dzip3, the E3 ligase of H2AK119, represses differentiation-inducible genes, as does Ring1B. The two sets of target genes partially overlapped but had different spectra. We found that Dzip3 represses gene expression by orchestrating changes in 3D organization, in addition to regulating ubiquitylation of H2A. Our results shed light on the epigenetic mechanism of transcriptional regulation, which depends on 3D chromatin reorganization to regulate mES cell differentiation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 5, 16567; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep16567","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015, Nature Publishing Group."},{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Daishi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aihara, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Tatsuharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizusaki, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doiguchi, Masamichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashi, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoneda, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyanishi, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okuda, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagawa, Takeya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"SciRep5_16567.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep5_16567.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4936/files/SciRep5_16567.pdf"},"version_id":"43c97c1a-662c-4c14-9fa3-2581d4e9287d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-21"},"publish_date":"2015-12-21","publish_status":"0","recid":"4936","relation_version_is_last":true,"title":["Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:14:10.847136+00:00"}