{"created":"2023-05-15T16:32:55.285290+00:00","id":4953,"links":{},"metadata":{"_buckets":{"deposit":"cc9e53e2-4955-42df-a7be-1e3e6919d776"},"_deposit":{"created_by":2,"id":"4953","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4953"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004953","sets":["29:30"]},"author_link":["20285","20291","20294","20286","20289","20292","20284","20287","20293","20288","20283","20290"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"856","bibliographicPageStart":"849","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Journal of Infection and Chemotherapy"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Verigene Gram-positive blood culture test (BC-GP) and the Verigene Gram-negative blood culture test (BC-GN) identify representative Gram-positive bacteria, Gram-negative bacteria and their antimicrobial resistance by detecting resistance genes within 3 h. Significant benefits are anticipated due to their rapidity and accuracy, however, their clinical utility is unproven in clinical studies. We performed a clinical trial between July 2014 and December 2014 for hospitalized bacteremia patients. During the intervention period (N = 88), Verigene BC-GP and BC-GN was used along with conventional microbiological diagnostic methods, while comparing the clinical data and outcomes with those during the control period (N = 147) (UMIN registration ID: UMIN000014399). The median duration between the initiation of blood culture incubation and the reporting time of the Verigene system results was 21.7 h (IQR 18.2-26.8) and the results were found in 88% of the cases by the next day after blood cultures were obtained without discordance. The hospital-onset infection rate was higher in the control period (24% vs. 44%, p = 0.002), however, no differences were seen in co-morbidities and severity between the control and intervention periods. During the intervention period, the time of appropriate antimicrobial agents' initiation was significantly earlier than that in the control period (p = 0.001) and most cases (90%; 79/88) were treated with antimicrobial agents with in-vitro susceptibility for causative bacteria the day after the blood culture was obtained. The costs for antimicrobial agents were lower in the intervention period (3618 yen vs. 8505 yen, p = 0.001). The 30-day mortality was lower in the intervention period (3% vs. 13%, p = 0.019).","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Infection and Chemotherapy, 21(12), pp.849-856; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本化学療法学会・日本感染症学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jiac.2015.08.019","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341321X","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Hiromichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hitomi, Shigemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yaguchi, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamai, Kiyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Atsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamata, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokuda, Yasuharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koganemaru, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurihara, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagisawa, Hideji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JIC21_849.pdf","filesize":[{"value":"787.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JIC21_849.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4953/files/JIC21_849.pdf"},"version_id":"7a2d26bd-ffb1-4c7f-bb09-2a6ad9ce23de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antimicrobial stewardship","subitem_subject_scheme":"Other"},{"subitem_subject":"Bacteremia","subitem_subject_scheme":"Other"},{"subitem_subject":"Gram-negative bacteria","subitem_subject_scheme":"Other"},{"subitem_subject":"Gram-positive bacteria","subitem_subject_scheme":"Other"},{"subitem_subject":"Verigene system","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prospective intervention study with a microarray-based, multiplexed, automated molecular diagnosis instrument (Verigene system) for the rapid diagnosis of bloodstream infections, and its impact on the clinical outcomes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prospective intervention study with a microarray-based, multiplexed, automated molecular diagnosis instrument (Verigene system) for the rapid diagnosis of bloodstream infections, and its impact on the clinical outcomes"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-07"},"publish_date":"2016-01-07","publish_status":"0","recid":"4953","relation_version_is_last":true,"title":["Prospective intervention study with a microarray-based, multiplexed, automated molecular diagnosis instrument (Verigene system) for the rapid diagnosis of bloodstream infections, and its impact on the clinical outcomes"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:14:01.405624+00:00"}