{"created":"2023-05-15T16:32:55.584648+00:00","id":4960,"links":{},"metadata":{"_buckets":{"deposit":"9bea7fd7-01a6-4eed-bfee-11c6e30ede7c"},"_deposit":{"created_by":2,"id":"4960","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4960"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004960","sets":["29:30"]},"author_link":["20344","20345","20340","20348","20346","20347","20343","20341","20342"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1395","bibliographicPageStart":"1380","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Cell Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"For a skin wound to successfully heal, the cut epidermal-edge cells have to migrate forward at the interface between scab and healthy granulation tissue. Much is known about how lead-edge cells migrate, but very little is known about the mechanisms that enable active participation by cells further back. Here we show that ephrin-B1 and its receptor EphB2 are both upregulated in vivo, just for the duration of repair, in the first 70 or so rows of epidermal cells, and this signal leads to downregulation of the molecular components of adherens and tight (but not desmosomal) junctions, leading to loosening between neighbors and enabling shuffle room among epidermal cells. Additionally, this signaling leads to the shutdown of actomyosin stress fibers in these same epidermal cells, which may act to release tension within the wound monolayer. If this signaling axis is perturbed, then disrupted healing is a consequence in mouse and man. Epithelial migration is essential for skin wound healing.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cell Reports, 13(7), pp.1380-1395; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.celrep.2015.09.085","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 The Authors. Published by Elsevier Inc."},{"subitem_rights":"This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"22111247","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nunan, Robert"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Campbell, Jessica"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Ryoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pitulescu, Mara E."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jiang, Wen G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harding, Keith G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adams, Ralf H."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nobes, Catherine D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Martin, Paul"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"CelRep13_1380.pdf","filesize":[{"value":"9.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CelRep13_1380.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4960/files/CelRep13_1380.pdf"},"version_id":"5575e652-b2c0-47a2-af7c-b2c39850ec38"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-08"},"publish_date":"2016-01-08","publish_status":"0","recid":"4960","relation_version_is_last":true,"title":["Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T22:56:23.499126+00:00"}