{"created":"2023-05-15T16:29:39.868744+00:00","id":499,"links":{},"metadata":{"_buckets":{"deposit":"dfeb0bf5-76dc-4968-890c-fccb78b91690"},"_deposit":{"created_by":2,"id":"499","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"499"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000499","sets":["35:36"]},"author_link":["2662","2661","2660","2658","2659","2663"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"169","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Viruses"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by the East/Central/South African (ECSA) genotype. However, the pathogenesis of the genotype infection has not been fully explained. In this study, we examined the pathogenic potential of CHIKV ECSA genotype M-30 (M-30) by comparing it with that of African genotype S-27 (S-27) in mice. Following low titer infections in type-I IFN receptor KO (A129) mice, we found that the M-30 infection caused high and acute fatality compared with the S-27 infection. M-30-infected A129 mice showed higher viral loads in their central nervous systems and peripheral organs, and increased levels of IFN- responses in their brains. Interestingly, M-30-infected mice did not show the hypophagia and reductions in weight which were observed in S-27-infected mice. Our observations provide a novel explanation of the pathogenic mechanisms attributed to virus proliferation, anti-type-II IFN response and metabolic activity in the CHIKV ECSA virus in mice.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Viruses, 12(2), art.no.169; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/v12020169","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19994915","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ngwe, Tun  Mya Myat"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muthugala, Rohitha"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kyaw, Kyaw  Aung"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayasaka, Daisuke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"Viruses12_12020169.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Viruses12_12020169.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/499/files/Viruses12_12020169.pdf"},"version_id":"8bb40d51-1523-4c9e-a8fd-a22c6b8f9104"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CHIKV","subitem_subject_scheme":"Other"},{"subitem_subject":"ECSA","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse model","subitem_subject_scheme":"Other"},{"subitem_subject":"viral pathogenesis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-02-19"},"publish_date":"2020-02-19","publish_status":"0","recid":"499","relation_version_is_last":true,"title":["Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:15:44.642504+00:00"}