{"created":"2023-05-15T16:32:57.012401+00:00","id":4993,"links":{},"metadata":{"_buckets":{"deposit":"1b655ecc-181c-467e-8466-5b13c299627b"},"_deposit":{"created_by":2,"id":"4993","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4993"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004993","sets":["10:11"]},"author_link":["20536","20554","20560","20529","20538","20545","20559","20542","20553","20550","20527","20549","20533","20543","20552","20534","20544","20535","20555","20532","20531","20526","20557","20556","20547","20528","20551","20546","20540","20530","20548","20541","20539","20537","20558"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"777","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"BMC Research Notes"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Previous genome-wide association studies have evaluated the impact of common genetic variants and identified several non-HLA risk loci associated with autoimmune liver diseases. More recent genome-wide association studies and replication analyses reported an association between variants of the CARD10 polymorphism rs6000782 and risk of type 1 autoimmune hepatitis (AIH). In this case-control study, we genotyped 326 Japanese AIH patients and 214 control subjects. Results: Genomic DNA from 540 individuals of Japanese origin, including 326 patients with type-1 AIH and 214 healthy controls, was analyzed for two single nucleotide polymorphisms (SNPs) in the CARD10 gene. We selected CARD10 rs6000782 SNPs and genotyped these using PCR-RFLP method and direct sequencing. The Chi square test revealed that the rs6000782 variant alle (c) was not associated with the susceptibility for AIH in a Japanese population [p = 0.376, odds ratio (OR) 1.271, 95 % confidence interval (CI) 0.747-2.161] in an allele model. Our data also showed that CARD10 rs6000782 variants were not associated with AIH or with the clinical parameters of AIH. Conclusions: In this study we examined an association between rs6000782 SNPs in the CARD10 gene and type-1 AIH. Results showed no significant association of rs62000782 with type-1 AIH in a Japanese population. This study demonstrated no association between CARD10 rs6000782 variants and AIH in a Japanese population.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BMC Research Notes, 8, 777; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13104-015-1733-4","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Migita et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"17560500","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Migita, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jiuchi, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furukawa, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komori, Atsumasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasunami, Michio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kozuru, Hideko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Seigo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, Kazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagaoka, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bekki, Shigemune"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizawa, Kaname"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kouno, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamitsukasa, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komatsu, Tatsuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hijioka, Taizo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamuta, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naganuma, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Haruhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohta, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ario, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oohara, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugi, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomizawa, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Takeaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Hironao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muro, Toyokichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makita, Fujio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mita, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Hironori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatsuhashi, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BMCRN8_777.pdf","filesize":[{"value":"964.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCRN8_777.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4993/files/BMCRN8_777.pdf"},"version_id":"f66bea7f-35d2-41a8-81c9-4dadd5ffbc14"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Autoimmune hepatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"CARD10","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetic factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Genome-wide association study","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-25"},"publish_date":"2016-01-25","publish_status":"0","recid":"4993","relation_version_is_last":true,"title":["Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:13:19.315556+00:00"}