{"created":"2023-05-15T16:32:58.334282+00:00","id":5024,"links":{},"metadata":{"_buckets":{"deposit":"d664965b-9ef4-4d80-86ae-93bf5df3b9f2"},"_deposit":{"created_by":2,"id":"5024","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5024"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005024","sets":["29:30:1713167819629:311"]},"author_link":["20656","20653","20654","20660","20659","20658","20652","20661","20655","20657"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"37","bibliographicPageStart":"33","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Serum Lactate Dehydrogenase (LDH) activity and soluble IL-2 Receptor-alpha (sIL-2R) levels are monitored as a marker of\ndisease activity in patients with lymphoma. Although adult T-cell leukemia (ATL) cells are well known to release large amounts of\nsIL-2R,it remains unclear to what extent B-cell lymphoma cells shed sIL-2R in sera. Subtypes of mature B-cell lymphoma, including\nCD25+ hairy leukemic cells, were examined for the characteristics of sIL-2R levels in each subtype. In normal controls, the\nserum sIL-2R mean value was 260u/mL.The median serum sIL-2R value for 64 B-cell lymphoma cases was 506 u/mL;by subtype\nthe median values were as follows: 1157 u/mL for 7 cases of chronic lymphocytic leukemia/hairy cell leukemia (CLL/HCL), 451\nu/mL for 38 cases of diffuse large B-cell lymphoma (DLBCL), and 456 u/mL for 19 cases of follicular Lymphoma (FL). The median\nvalues of serum LDH activity by the above subtypes were 175 IU/mL, 204 IU/mL, and 198 IU/mL, respectively. There was\ndistinct inter-subtype and inter-patient variation of serum sIL-2R.In particular, inter-case variation could be grouped into value for\nthree concentration ranges: less than 300 u/mL, 300-1000 u/mL, and greater than 1000 u/mL. Cases with serum sIL-2R values\nof 1000 u/mL or more tended to have an especially high sIL-2R to LDH ratio, suggesting a close relationship between high sIL-2R\nand CD25-expressing lymphoma cells. With respect to sIL-2R and LDH levels, CLL/HCL, DLBCL, and FL showed similar distributions.\nMoreover, for sIL-2R levels exceeding 1000u/mL, sIL-2R levels were randomly high according to the LDH status. Conclusively,\nthe combination of serum sIL-2R level and LDH activity can provide a better understanding of characteristics of subtypes\nof mature B-Cell Lymphoma and can be used as a reliable surrogate marker for evaluating numerical and biological data.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 60(2), pp.33-37; 2016","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"1"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Reiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamihira, Shimeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsubara, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Shouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinoshita, Kazuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Youichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanematsu, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Kazuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"De, Kerckhove  Charles"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ActMed60_33.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed60_33.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5024/files/ActMed60_33.pdf"},"version_id":"fde402ca-add8-4de5-b480-819f7ac32b55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sIL-2R","subitem_subject_scheme":"Other"},{"subitem_subject":"bio-marker","subitem_subject_scheme":"Other"},{"subitem_subject":"RI","subitem_subject_scheme":"Other"},{"subitem_subject":"B-ML","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quantitative Features of serum sIL-2R level in Patients with Mature B-Cell Lymphoma? Involvement of LDH","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quantitative Features of serum sIL-2R level in Patients with Mature B-Cell Lymphoma? Involvement of LDH"}]},"item_type_id":"3","owner":"2","path":["311"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-09"},"publish_date":"2016-02-09","publish_status":"0","recid":"5024","relation_version_is_last":true,"title":["Quantitative Features of serum sIL-2R level in Patients with Mature B-Cell Lymphoma? Involvement of LDH"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-04-16T05:28:10.573738+00:00"}