{"created":"2023-05-15T16:32:58.600372+00:00","id":5030,"links":{},"metadata":{"_buckets":{"deposit":"dd307547-a1ff-4759-9386-ba66fb248e9c"},"_deposit":{"created_by":2,"id":"5030","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5030"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005030","sets":["29:30:1713167819629:311"]},"author_link":["20704","20698","20697","20701","20705","20702","20703","20700","20699"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"84","bibliographicPageStart":"77","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The toll-like receptor 4 (TLR4)-mediated immune response is considered as one of the triggers of acute respiratory distress\nsyndrome. The agonistic monoclonal antibody UT12 specific for the TLR4/MD2 complex induces immune activation in a manner\ndistinct from lipopolysaccharide (LPS). In order to compare the effects of this differential TLR4 signaling activation, we examined\nimmune cell recruitment to the lung following intratracheal inoculation with UT12 and LPS in mice. The increase in pulmonary\nneutrophils was much higher after LPS treatment compared with UT12 treatment, while CD11bhiCD11＋cells increased to similar\nlevels following both treatments. These changes were MyD88-dependent and TRIF-independent. These differential effects on\nimmune cell recruitment to the lung suggest distinct underlying mechanisms in response to TLR4 stimulation. These findings\nfurther indicate that TLR signaling can lead to different outcomes depending on the ligand and activation pathway, which may\nrelate to the complex pathogenesis of inflammatory lung diseases.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 60(2), pp.77-84; 2016","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"7"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inamura, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, Kiri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyakoda, Mana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Kazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukudome, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nanashima, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayasu, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yui, Katsuyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ActMed60_77.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed60_77.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5030/files/ActMed60_77.pdf"},"version_id":"1aaf54f8-d632-4ed8-9662-5e31a4119166"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lung","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR4","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophils","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations"}]},"item_type_id":"3","owner":"2","path":["311"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-10"},"publish_date":"2016-02-10","publish_status":"0","recid":"5030","relation_version_is_last":true,"title":["Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-04-16T05:28:11.685197+00:00"}