@phdthesis{oai:nagasaki-u.repo.nii.ac.jp:00000513,
 author = {DE, VERA LUZ  MARK ANTHONY},
 month = {Sep},
 note = {Dengue remains a major public health problem in the Philippines. In this study, we determined the circulating dengue serotypes in the Philippines during the 2015?2017 outbreaks using a total of 678 serum samples from 537 individual dengue patients. Following an increase in the number of DENV-4 patients in recent years, we conducted a comprehensive molecular and epidemiology analysis on the DENV-4 strains isolated recently in the Philippines. Two genotypes of DENV-4 have been isolated in the Philippines since 1956: GI and GIIa. The GIIa DENV strains that were isolated in the present study were closely related to a distinct group of GIIa strains that were isolated from the Philippines in 2004. A majority of the isolates of this sub-group have been identified in the Philippines, suggesting that this lineage may have been introduced in the Philippines, and evolved to form the distinct sub-group within GIIa strains. The increase in DENV-4 activity also coincided with the appearance of the GIIa subgroup and the phasing-out of the GI lineage in the Philippines. Overall, our study demonstrates a shift in DENV-4 genotype and epidemic dynamics in a hyperendemic region, suggesting the importance of DENV genetic evolution in establishing and sustaining transmission., 長崎大学学位論文 学位記番号:博(医歯薬)甲第1187号 学位授与年月日:令和元年9月20日, Author: Mark Anthony de Vera Luz, Takeshi Nabeshima, Meng Ling Moi, Maria Terrese Alonzo Dimamay, Lady-Anne Suarez Pangilinan, Mark Pierre Sijo Dimamay, Ronald Roll Matias, Cynthia Abad Mapua, Corazon Cerilla Buerano, Ferdinand de Guzman, Edith Sangalang Tria, Filipinas Florendo Natividad, Maria Luisa de Guzman Daroy, Taichiro Takemura, Futoshi Hasebe, Kouichi Morita, Citation: Japanese Journal of Infectious Diseases, 72(6), pp.413-419; 2019, 出版時論題変更, Nagasaki University (長崎大学), 博士(医学) (2019-09-20)},
 school = {Nagasaki University (長崎大学)},
 title = {Dengue virus serotype-4 during the 2015-2017 epidemic: emergence of a novel genotype IIa of DENV-4 in the Philippines},
 year = {2019}
}