| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-04-15 |
| タイトル |
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タイトル |
Effect of Cytokines on Osteoclast Formation and Bone Resorption during Mechanical Force Loading of the Periodontal Membrane |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kitaura, Hideki
Kimura, Keisuke
Ishida, Masahiko
Sugisawa, Haruki
Kohara, Haruka
Yoshimatsu, Masako
Takano-Yamamoto, Teruko
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Mechanical force loading exerts important effects on the skeleton by controlling bone mass and strength. Several in vivo experimental models evaluating the effects of mechanical loading on bone metabolism have been reported. Orthodontic tooth movement is a useful model for understanding the mechanism of bone remodeling induced by mechanical loading. In a mouse model of orthodontic tooth movement, TNF-α was expressed and osteoclasts appeared on the compressed side of the periodontal ligament. In TNF-receptor-deficient mice, there was less tooth movement and osteoclast numbers were lower than in wild-type mice. These results suggest that osteoclast formation and bone resorption caused by loading forces on the periodontal ligament depend on TNF-α. Several cytokines are expressed in the periodontal ligament during orthodontic tooth movement. Studies have found that inflammatory cytokines such as IL-12 and IFN-γ strongly inhibit osteoclast formation and tooth movement. Blocking macrophage colony-stimulating factor by using anti-c-Fms antibody also inhibited osteoclast formation and tooth movement. In this review we describe and discuss the effect of cytokines in the periodontal ligament on osteoclast formation and bone resorption during mechanical force loading. |
| 書誌情報 |
The Scientific World Journal
巻 2014,
p. 1-7,
発行日 2014-01-19
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| 出版者 |
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出版者 |
Hindawi Publishing Corporation |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
23566140 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1537744X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1155/2014/617032 |
| 権利 |
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権利情報 |
c 2014 Hideki Kitaura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
The Scientific World Journal, 2014, 617032; 2014 |
SWJ2014_617032.pdf (473.1 kB)
