{"created":"2023-05-15T16:33:07.620777+00:00","id":5239,"links":{},"metadata":{"_buckets":{"deposit":"3b256617-a03a-4d96-9235-d30e29fad664"},"_deposit":{"created_by":2,"id":"5239","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5239"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005239","sets":["8:9"]},"author_link":["21938","21937","21932","21939","21935","21933","21934","21936"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1172","bibliographicPageStart":"1163","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Osteoporosis International"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Once-weekly administration of 56.5 μg teriparatide improved cortical bone parameters and biomechanical parameters at the proximal femur by CT geometry analysis. Introduction: The aim of this study was to evaluate the effects of weekly administration of teriparatide [human PTH (1-34)] on bone geometry, volumetric bone mineral density (vBMD), and parameters of bone strength at the proximal femur which were longitudinally investigated using computed tomography (CT). Methods: The subjects were a subgroup of a recent, randomly assigned, double-blind study (578 subjects) comparing the anti-fracture efficacy of a once-weekly subcutaneous injection of 56.5 μg teriparatide with placebo (TOWER trial). Results: Sixty-six ambulatory postmenopausal women with osteoporosis were enrolled at 15 study sites having multi-detector row CT, and included women injected with teriparatide (n = 29, 74.2 ± 5.1 years) or with placebo (n = 37, 74.8 ± 5.3 years). CT data were obtained at baseline and follow-up scans were performed at 48 and 72 weeks. The data were analyzed to obtain cross-sectional densitometric, geometric, and biomechanical parameters including the section modulus (SM) and buckling ratio (BR) of the femoral neck, inter-trochanter, and femoral shaft. We found that once-weekly teriparatide increased cortical thickness/cross-sectional area (CSA) and total area, and improved biomechanical properties (i.e., decreasing BR) at the femoral neck and shaft. Teriparatide did not change the cortical perimeter. Conclusions: Our longitudinal analysis of proximal femur geometry by CT revealed that once-weekly administration of 56.5 μg teriparatide improved cortical bone parameters at the femoral neck and shaft and also improved biomechanical parameters.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Osteoporosis International, 25(3), pp.1163-1172; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer London"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00198-013-2596-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s) 2013. This article is published with open access at Springerlink.com"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0937941X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14332965","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oishi, R."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukunaga, Masao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sone, T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Toshitsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraki, M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishizawa, Y."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Toshitaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"OI25_1163.pdf","filesize":[{"value":"648.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OI25_1163.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5239/files/OI25_1163.pdf"},"version_id":"fd2a4238-c7e2-4c8f-ad89-41c4ff20c960"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Once-weekly injection","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoporosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Proximal femur geometry","subitem_subject_scheme":"Other"},{"subitem_subject":"Quantitative computed tomography","subitem_subject_scheme":"Other"},{"subitem_subject":"Teriparatide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-04-22"},"publish_date":"2014-04-22","publish_status":"0","recid":"5239","relation_version_is_last":true,"title":["The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:09:19.314804+00:00"}