{"created":"2023-05-15T16:33:08.053839+00:00","id":5249,"links":{},"metadata":{"_buckets":{"deposit":"cc1ee11a-50c2-464a-9e32-dd4dd9f11b8d"},"_deposit":{"created_by":2,"id":"5249","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5249"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005249","sets":["29:30"]},"author_link":["22018","22015","22021","22016","22017","22019","22020"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-22","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"302","bibliographicPageStart":"297","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Medical Science Monitor"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Cysteinyl leukotrienes (cys-LTs) are very important factors in the pathophysiology of bronchial asthma. Cys-LT receptor antagonists (LTRAs) decrease allergic airway inflammation. The aim of the present study was to determine the differential effects of LTRAs and corticosteroids on allergic airway inflammation and allergen-specific cytokine production from lymphoid tissues using a murine model of asthma. Material/Methods: Four groups of female BALB/c mice [control (Cont); Dermatophagoides farinae allergen-sensitized (AS); pranlukast (Prl), an LTRA-treated AS; and dexamethasone (Dex)-treated AS] were examined. Lung pathology and cytokine production by prepared mononuclear cells isolated from mediastinal lymph nodes (MLNs) and spleen were compared among these groups. Results: AS mice exhibited allergic airway inflammation and significant increases in allergen-specific Th1 and Th2 cytokines in MLNs and spleen. Prl-treated mice showed significant attenuation of allergic airway inflammation concomitant with reduction of Th2 cytokines and IFN-g in MLNs but not in spleen. In contrast, Dex significantly decreased Th1 and Th2 cytokines in MLNs and also decreased them (except IL-13 and IL-2) in spleen. Conclusions: The inflammatory effects of cys-LTs could differ in lymphoid organs. LTRAs potentially regulate allergic airway inflammation in an organ- and cytokine-specific manner, while systemic corticosteroid shows nonspecific effects.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Medical Science Monitor, 20, pp.297-302; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Scientific Literature Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.12659/MSM.889865","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Med Sci Monit, 2014."},{"subitem_rights":"This work is licensed under a Creative Commons\nAttribution-NonCommercial-NoDerivs 3.0 Unported License"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"16433750","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawano, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuse, Hiroto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchida, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukahori, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Chizu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MSM20_297.pdf","filesize":[{"value":"497.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MSM20_297.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5249/files/MSM20_297.pdf"},"version_id":"03e4eff1-20dc-4a22-989a-246b6cacbed8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Asthma","subitem_subject_scheme":"Other"},{"subitem_subject":"Leukotriene antagonists","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphoid tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"Pranlukast","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-04-23"},"publish_date":"2014-04-23","publish_status":"0","recid":"5249","relation_version_is_last":true,"title":["Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:08:59.916262+00:00"}