{"created":"2023-05-15T16:33:09.518953+00:00","id":5282,"links":{},"metadata":{"_buckets":{"deposit":"b0e0b483-72dc-411f-b7cd-a2a852eafb67"},"_deposit":{"created_by":2,"id":"5282","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5282"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005282","sets":["8:9"]},"author_link":["22144","22150","22149","22148","22143","22146","22147","22145","22151"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"239","bibliographicPageStart":"236","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Pancreas"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVES: Zinc (Zn) is related to insulin synthesis, storage, and secretion. This study demonstrates the effects of Zn supplementation in donor rats on the outcomes of islet transplantation. METHODS: Donor rats received 3 different regimens of dietary Zn supplementation for 2 weeks before undergoing pancreas donation: a standard diet containing Zn at 50 ppm (control), 1 ppm (low-Zn group) or 1000 ppm (high-Zn group), respectively. Diabetic recipient rats underwent islet transplantation, and the blood glucose levels and insulin secretion were monitored for 7 days after transplantation. RESULTS: The serum and pancreatic Zn levels at the time of donation were significantly lower in the low-Zn group (48.8 ± 25.5 μg/dL and 11.3 ± 1.9 μg/g) and higher in the high-Zn group (147.3 ± 17.6 μg/dL and 18.7 ± 2.2 μg/g) when compared with those observed in the controls (118.7 ± 7.9 μg/dL and 14.6 ± 2.0 μg/g) (P < 0.05). The blood glucose levels became re-elevated 2 days after transplantation in rats receiving islet grafts from the controls and the low-Zn groups. In contrast, in the rats that received islets from the high-Zn groups, these were maintained within a reference range (P < 0.01). CONCLUSIONS: These data indicate that a Zn-rich diet for donor rats improves the function of islet grafts in chemically induced diabetic rats.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Pancreas, 43(2), pp.236-239; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott Williams and Wilkins"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/MPA.0000000000000093","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 by Lippincott Williams and Wilkins."},{"subitem_rights":"This is a non-final version of an article published in final form in Pancreas, 43(2), pp.236-239; 2014"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"08853177","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mishima, Takehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuroki, Tamotsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tajima, Yoshitsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adachi, Tomohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirabaru, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitasato, Amane"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuki, Mitsuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Susumu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"Pancreas43_236.pdf","filesize":[{"value":"284.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Pancreas43_236.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5282/files/Pancreas43_236.pdf"},"version_id":"16c08eb9-4177-41cf-badc-2f72e9963c07"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dietary supplementation","subitem_subject_scheme":"Other"},{"subitem_subject":"graft function","subitem_subject_scheme":"Other"},{"subitem_subject":"islet transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"type 1 diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"zinc","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-01"},"publish_date":"2015-04-01","publish_status":"0","recid":"5282","relation_version_is_last":true,"title":["Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:08:16.994896+00:00"}