{"created":"2023-05-15T16:29:41.319721+00:00","id":533,"links":{},"metadata":{"_buckets":{"deposit":"34f20421-9d2e-4e72-8055-643dbe5ace03"},"_deposit":{"created_by":2,"id":"533","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"533"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000533","sets":["10:11"]},"author_link":["2799","2802","2800","2801","2804","2803","2805"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"7","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Environmental Health and Preventive Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Anti-thyroid peroxidase antibody (TPO-Ab) has been shown to cause autoimmune thyroiditis by inducing a deleterious influence on thyroid hormone synthesis. Further, thyroglobulin, which has an important role in thyroid hormone synthesis, is reported to be high in the fluid from thyroid cysts. Therefore, TPO-Ab could be associated with the presence of thyroid cyst, partly by affecting the activity of thyroid hormone synthesis. METHODS: To investigate the association between TPO-Ab and thyroid cysts, we conducted a cross-sectional study of 1432 Japanese with normal thyroid function [i.e., normal range of free triiodothyronine (free T3) and free thyroxine (free T4)] between the ages of 40 and 74?years, who participated in an annual health check-up. RESULTS: In men, the statistical power did not reach a statistical significance value. Additionally, subjects with TPO-Ab showed lower odds ratios (ORs) of thyroid cysts than those without TPO-Ab. In women, subjects with TPO-Ab showed significantly lower ORs of thyroid cysts than those without TPO-Ab. The fully adjusted ORs were 0.68 (0.40, 1.18) for men and 0.40 (0.27, 0.60) for women. When evaluating the association between logarithmic values of TPO-Ab titer and thyroid cysts in both men and women, a notable inverse correlation was observed. The fully adjusted ORs were 0.68 (0.50, 0.92) for men and 0.68 (0.57, 0.81) for women. CONCLUSION: TPO-Ab titer revealed to be inversely associated with thyroid cysts among Japanese with normal thyroid function. The presence of a thyroid cyst could indicate a lower risk of having TPO-Ab among the general population with normal thyroid function.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Environmental health and preventive medicine, 25(1), art.no.7; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12199-020-00844-x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waive (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1342078X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474715","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nabeshima-Kimura, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noguchi, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Naomi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"EHPM25_7.pdf","filesize":[{"value":"308.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EHPM25_7.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/533/files/EHPM25_7.pdf"},"version_id":"7b64e9fd-c4d5-40ac-8d6a-bcd6c9cd6b6c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anti-thyroid peroxidase antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"Cross-sectional study","subitem_subject_scheme":"Other"},{"subitem_subject":"Normal thyroid function","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroid cysts","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroid hormone","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-13"},"publish_date":"2020-03-13","publish_status":"0","recid":"533","relation_version_is_last":true,"title":["Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:15:20.233009+00:00"}