{"created":"2023-05-15T16:33:11.663252+00:00","id":5331,"links":{},"metadata":{"_buckets":{"deposit":"65742b4f-9a39-4b21-8b5a-019def215048"},"_deposit":{"created_by":2,"id":"5331","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5331"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005331","sets":["29:30"]},"author_link":["22464","22462","22458","22467","22461","22463","22459","22466","22457","22456","22465","22455","22460"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4517","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 4, 4517; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep04517","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chiba, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"22455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamashiro, Yukari"}],"nameIdentifiers":[{"nameIdentifier":"22456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Park, Daeui"}],"nameIdentifiers":[{"nameIdentifier":"22457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kusudo, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"22458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujie, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"22459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komatsu, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"22460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Sang Eun"}],"nameIdentifiers":[{"nameIdentifier":"22461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Park, Seongjoon"}],"nameIdentifiers":[{"nameIdentifier":"22462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"22463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"22464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamashita, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"22465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chung, Hae Young"}],"nameIdentifiers":[{"nameIdentifier":"22466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Isao"}],"nameIdentifiers":[{"nameIdentifier":"22467","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"SciRep4_4517.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep4_4517.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5331/files/SciRep4_4517.pdf"},"version_id":"618acea5-6c1f-460a-8813-d2671c9b1416"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-21"},"publish_date":"2014-05-21","publish_status":"0","recid":"5331","relation_version_is_last":true,"title":["A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:07:10.282884+00:00"}