@article{oai:nagasaki-u.repo.nii.ac.jp:00005349,
 author = {Yamamoto, Kazuo and Gandin, Valentina and Sasaki, Masato and McCracken, Susan and Li, Wanda and Silvester, Jennifer Liepa and Elia, Andrew J. and Wang, Feng and Wakutani, Yosuke and Alexandrova, Roumiana and Oo, Yathor D and Mullen, Peter J. and Inoue, Satoshi and Itsumi, Momoe and Lapin, Valentina and Haight, Jillian and Wakeham, Andrew and Shahinian, Arda and Ikura, Mitsuhiko and Topisirovic, Ivan and Sonenberg, Nahum and Mak, Tak W.},
 issue = {6},
 journal = {Molecular Cell},
 month = {Mar},
 note = {Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human cells. Invitro evidence indicated that Largen preferentially stimulates the translation of specific subsetsof mRNAs, including those encoding proteins affecting mitochondrial functions. The involvement of Largen in mitochondrial respiration was consistentwith the increased mitochondrial mass and greater ATP production in Largen-overexpressing cells. Furthermore, Largen overexpression led to increased cell size invivo, as revealed by analyses of conditional Largen transgenic mice. Our results establish Largen as an important link between mRNA translation, mitochondrial functions, and the control of mammalian cell size., Molecular Cell, 53(6), pp.904-915; 2014},
 pages = {904--915},
 title = {Largen: A Molecular Regulator of Mammalian Cell Size Control},
 volume = {53},
 year = {2014}
}