@article{oai:nagasaki-u.repo.nii.ac.jp:00005387,
 author = {Eguchi, Susumu and Takatsuki, Mitsuhisa and Soyama, Akihiko and Hidaka, Masaaki and Nakao, Kazuhiko and Shirasaka, Takuma and Yamamoto, Masahiro and Tachikawa, Natsuo and Gatanaga, Hiroyuki and Kugiyama, Yuki and Yatsuhashi, Hiroshi and Ichida, Takafumi and Kokudo, Norihiro},
 issue = {3},
 journal = {Transplantation Proceedings},
 month = {Apr},
 note = {Background As the survival of human immunodeficiency virus (HIV)-infected individuals has improved due to the widespread use of antiretroviral therapy, the mortality rate due to hepatitis C virus (HCV)-related liver disease has increased in HIV/HCV-coinfected patients. Aim The aims of this study were to establish the appropriate therapeutic strategy for HIV/HCV-coinfected patients by evaluating the liver function, including the hepatic functional reserve and portal hypertension, and to investigate the prognosis of HIV/HCV-coinfected patients in Japan. Patients and Methods In addition to regular liver function tests, the hepatic functional reserve of 41 patients with HIV/HCV coinfection was evaluated using the indocyanine green retention rate and liver galactosyl serum albumin-scintigraphy. The data for 146 patients with HIV/HCV coinfection through blood products were extracted from 4 major HIV centers in Japan. In addition to liver function tests, the platelet counts (PLT) were evaluated as a marker of portal hypertension. Results In spite of the relatively preserved general liver function test results, approximately 40% of the HIV/HCV-coinfected patients had an impaired hepatic functional reserve. In addition, while the albumin and bilirubin levels were normal, the PLT was <150,000/μL in 17 patients. Compared with HCV mono-infected patients with a PLT <150,000/μL, the survival of HIV/HCV-coinfected patients was shorter (HCV, 5 years, 97%; 10 years, 86% and HIV/HCV, 5 years, 87%; 10 years, 73%; P <.05). Conclusion These results must be taken into account to establish an optimal therapeutic strategy, including the appropriate timing of liver transplantation in HIV/HCV-coinfected patients in Japan., Transplantation Proceedings, 46(3), pp.736-738; 2014},
 pages = {736--738},
 title = {Analysis of the Hepatic Functional Reserve, Portal Hypertension, and Prognosis of Patients With Human Immunodeficiency Virus/Hepatitis C Virus Coinfection Through Contaminated Blood Products in Japan},
 volume = {46},
 year = {2014}
}