{"created":"2023-05-15T16:33:24.338256+00:00","id":5625,"links":{},"metadata":{"_buckets":{"deposit":"297129dc-de9c-46c1-bf52-dc0994aa6ece"},"_deposit":{"created_by":2,"id":"5625","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5625"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005625","sets":["27:28"]},"author_link":["23867","23863","23864","23862","23866","23865"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"217","bibliographicPageStart":"212","bibliographicVolumeNumber":"446","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cathepsin E is an intracellular aspartic proteinase, which is predominantly distributed in immune-related and epithelial cells. However, the role of the enzyme in adipose tissues remains unknown. In this study, we investigated the characteristics of cathepsin E-deficient (CatE-/-) mice fed a high-fat diet (HFD), as a mouse model of obesity. HFD-fed CatE-/- mice displayed reduced body weight gain and defective development of white adipose tissue (WAT) and brown adipose tissue (BAT), compared with HFD-fed wild-type mice. Moreover, fat-induced CatE-/- mice showed abnormal lipid accumulation in non-adipose tissues characterized by hepatomegaly, which is probably due to defective adipose tissue development. Detailed pathological and biochemical analyses showed that hepatomegaly was accompanied by hepatic steatosis and hypercholesterolemia in HFD-induced CatE-/- mice. In fat-induced CatE-/- mice, the number of macrophages infiltrating into WAT was significantly lower than in fat-induced wild-type mice. Thus, the impaired adipose tissue development in HFD-induced CatE-/- mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biochemical and Biophysical Research Communications, 446(1), pp.212-217; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Academic Press Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2014.02.089","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Elsevier Inc. All rights reserved."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in Biochemical and Biophysical Research Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochemical and Biophysical Research Communications, 446, 1, (2014)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kadowaki, Tomoko"}],"nameIdentifiers":[{"nameIdentifier":"23862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kido, Mizuho A."}],"nameIdentifiers":[{"nameIdentifier":"23863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatakeyama, Junko"}],"nameIdentifiers":[{"nameIdentifier":"23864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okamoto, Kuniaki"}],"nameIdentifiers":[{"nameIdentifier":"23865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukuba, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"23866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"23867","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BBRC446_212.pdf","filesize":[{"value":"925.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BBRC446_212.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5625/files/BBRC446_212.pdf"},"version_id":"d1a4f333-32e9-4ac8-939b-12a02f1c0c53"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adipose tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"Cathepsin E","subitem_subject_scheme":"Other"},{"subitem_subject":"High-fat diet","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet"}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-29"},"publish_date":"2014-09-29","publish_status":"0","recid":"5625","relation_version_is_last":true,"title":["Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:02:12.391511+00:00"}