{"created":"2023-05-15T16:33:26.225796+00:00","id":5669,"links":{},"metadata":{"_buckets":{"deposit":"61b64b74-7ae9-432e-b358-93d04d9359ea"},"_deposit":{"created_by":2,"id":"5669","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5669"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005669","sets":["25:26"]},"author_link":["24155","24156","24161","24153","24157","24151","24160","24159","24152","24154","24158"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-08-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"e104279","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Different levels or types of DNA damage activate distinct signaling pathways that elicit various cellular responses, including cell-cycle arrest, DNA repair, senescence, and apoptosis. Whereas a range of DNA-damage responses have been characterized, mechanisms underlying subsequent cell-fate decision remain elusive. Here we exposed cultured cells and mice to different doses and dose rates of γ-irradiation, which revealed cell-type-specific sensitivities to chronic, but not acute, γ-irradiation. Among tested cell types, human fibroblasts were associated with the highest levels of growth inhibition in response to chronic γ-irradiation. In this context, fibroblasts exhibited a reversible G1 cell-cycle arrest or an irreversible senescence-like growth arrest, depending on the irradiation dose rate or the rate of DNA damage. Remarkably, when the same dose of γ-irradiation was delivered chronically or acutely, chronic delivery induced considerably more cellular senescence. A similar effect was observed with primary cells isolated from irradiated mice. We demonstrate a critical role for the ataxia telangiectasia mutated (ATM)/tumor protein p53 (TP53)/p21 pathway in regulating DNA-damage-associated cell fate. Indeed, blocking the ATM/TP53/p21 pathway deregulated DNA damage responses, leading to micronucleus formation in chronically irradiated cells. Together these results provide insights into the mechanisms governing cell-fate determination in response to different rates of DNA damage.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 9(8), e104279; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0104279","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Cao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Cao, Lili"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawai, Hidehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasatani, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iizuka, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaba, Toshiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ootsuyama, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umata, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamiya, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Fumio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"PLoS9_104279.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS9_104279.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5669/files/PLoS9_104279.pdf"},"version_id":"a1a86085-06c6-4691-ba9e-98c07b481c4e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-06"},"publish_date":"2014-10-06","publish_status":"0","recid":"5669","relation_version_is_last":true,"title":["A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:01:09.712888+00:00"}