@article{oai:nagasaki-u.repo.nii.ac.jp:00005676,
 author = {Fukahori, Susumu and Matsuse, Hiroto and Tsuchida, Tomoko and Kawano, Tetsuya and Nishino, Tomoya and Fukushima, Chizu and Kohno, Shigeru},
 issue = {2},
 journal = {Annals of Allergy, Asthma & Immunology},
 month = {Aug},
 note = {Background Aspergillus fumigatus (Af) sometimes colonizes and persists within the respiratory tree in some patients with asthma. To date, the precise reasons why the clearance of Af is impaired in patients with asthma remain unknown. Objective To characterize the effects of allergic airway inflammation on clearance of Af. Methods Control and Dermatophagoides farinae (Df) allergen-sensitized BALB/c mice were intranasally infected with Af. After 2 and 9 days of infection, the pathology, fungal burden, and cytokine profile in lung tissue were compared. In a different set of experiments, the phagocytotic activity of alveolar macrophages and the expression of their pathogen recognition receptors also were determined. Results The Af conidia and neutrophilic airway inflammation disappeared by day 9 after infection in control mice. In Df-sensitized mice, Af conidia and neutrophilic and eosinophilic airway inflammation persisted at day 9 after infection. Compared with control mice, Df allergen-sensitized mice showed significant increases in interleukin (IL)-5 and decreases in IL-12 and interferon-γ in lung tissues at day 2 after infection. Most importantly, compared with Af-infected non-Df-sensitized mice, IL-17 in lung tissues was significantly decreased in Df allergen-sensitized Af-infected mice at day 2 after infection but was significantly increased at day 9. Alveolar macrophages isolated from Df allergen-sensitized mice exhibited significant decreases in phagocytotic activity and expression of Toll-like receptor-4 and dectin-1 compared with those from control mice. Conclusion In the airway of patients with allergy, T-helper cell type 2-dominant immunity potentially affects the expression of pathogen recognition receptors and attenuates cellular defense against Af. Prolonged IL-17 production also could play an important role., Annals of Allergy, Asthma & Immunology, 113(2), pp.180-186; 2014},
 pages = {180--186},
 title = {Clearance of Aspergillus fumigatus is impaired in the airway in allergic inflammation},
 volume = {113},
 year = {2014}
}