{"created":"2023-05-15T16:33:26.952909+00:00","id":5686,"links":{},"metadata":{"_buckets":{"deposit":"3af61e6f-77a4-414c-b849-0e007e02ded9"},"_deposit":{"created_by":2,"id":"5686","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5686"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005686","sets":["25:26"]},"author_link":["24297","24306","24303","24304","24305","24296","24300","24295","24307","24302","24299","24308","24298","24301"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3779","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Scientific reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Effects of antioxidants on the quality and genomic stability of induced pluripotent stem (iPS) cells were investigated with two human iPS cell lines (201B7 and 253G1). Cells used in this study were expanded from a single colony of each cell line with the addition of proprietary antioxidant supplement or homemade antioxidant cocktail in medium, and maintained in parallel for 2 months. The cells grew well in all culture conditions and kept \"stemness\". Although antioxidants modestly decreased the levels of intracellular reactive oxygen species, there were no differences in the expression of 53BP1 and pATM, two critical molecules related with DNA damage and repair, under various culture conditions. CGH analysis showed that the events of genetic aberrations were decreased only in the 253G1 iPS cells with the addition of homemade antioxidant cocktail. Long-term culture will be necessary to confirm whether low dose antioxidants improve the quality and genomic stability of iPS cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific reports, 4, 3779; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"24445363","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep03779","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Luo, Lan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakatsu, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Guo, Chao-Wan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Urata, Yoshishige"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huang, Wen-Jing"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ali, Haytham"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doi, Hanako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitajima, Yuriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ono, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xin, Hong-Bo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamano, Kimikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Tao-Sheng"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"SciRep4_3779.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep4_3779.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5686/files/SciRep4_3779.pdf"},"version_id":"6e53ab3a-667f-40ed-86df-022a3512f142"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-10"},"publish_date":"2014-10-10","publish_status":"0","recid":"5686","relation_version_is_last":true,"title":["Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:00:47.299273+00:00"}