{"created":"2023-05-15T16:33:27.353152+00:00","id":5695,"links":{},"metadata":{"_buckets":{"deposit":"bb435b6d-a0e1-4510-9468-754344f70732"},"_deposit":{"created_by":2,"id":"5695","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5695"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005695","sets":["8:9"]},"author_link":["24385","24386","24384","24389","24379","24376","24377","24383","24381","24382","24390","24375","24391","24392","24387","24380","24378","24388"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1466","bibliographicPageStart":"1459","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Leukemia"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Myeloperoxidase (MPO) has been associated with both a myeloid lineage commitment and favorable prognosis in patients with acute myeloid leukemia (AML). DNA methyltransferase inhibitors (decitabine and zeburaline) induced MPO gene promoter demethylation and MPO gene transcription in AML cells with low MPO activity. Therefore, MPO gene transcription was directly and indirectly regulated by DNA methylation. A DNA methylation microarray subsequently revealed a distinct methylation pattern in 33 genes, including DNA methyltransferase 3 beta (DNMT3B), in CD34-positive cells obtained from AML patients with a high percentage of MPO-positive blasts. Based on the inverse relationship between the methylation status of DNMT3B and MPO, we found an inverse relationship between DNMT3B and MPO transcription levels in CD34-positive AML cells (P=0.0283). In addition, a distinct methylation pattern was observed in five genes related to myeloid differentiation or therapeutic sensitivity in CD34-positive cells from AML patients with a high percentage of MPO-positive blasts. Taken together, the results of the present study indicate that MPO may serve as an informative marker for identifying a distinct and crucial DNA methylation profile in CD34-positive AML cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Leukemia, 28(7), pp.1459-1466; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/leu.2014.15","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Macmillan Publishers Limited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"08876924","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14765551","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Itonaga, Hidehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imanishi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wong, Yan-Fung"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawayama, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruda, Kazuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imaizumi, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taguchi, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsushima, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Shinichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hata, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriuchi, Yukiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"Supplement.pdf","filesize":[{"value":"620.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Supplement.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5695/files/Supplement.pdf"},"version_id":"fe9f9a8d-a41a-451e-942a-619aa00642f0"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"Leukemia28_1459.pdf","filesize":[{"value":"926.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Leukemia28_1459.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5695/files/Leukemia28_1459.pdf"},"version_id":"8235d917-1c54-4f62-97e5-80d2c2156211"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"acute myeloid leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA methylation","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA methyltransferase 3 beta","subitem_subject_scheme":"Other"},{"subitem_subject":"myeloperoxidase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-01"},"publish_date":"2015-02-01","publish_status":"0","recid":"5695","relation_version_is_last":true,"title":["Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:00:31.689745+00:00"}