{"created":"2023-05-15T16:33:28.880174+00:00","id":5731,"links":{},"metadata":{"_buckets":{"deposit":"0bb93e8d-1a7f-4a1a-a21b-03397121c13b"},"_deposit":{"created_by":2,"id":"5731","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5731"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005731","sets":["8:9"]},"author_link":["24638","24627","24641","24634","24637","24630","24626","24639","24636","24635","24631","24628","24629","24640","24633","24632"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"109","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Respiratory Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is associated with high mortality. However, few studies have so far reviewed analyses of autopsy findings in patients with AE-IPF.Methods: We retrospectively reviewed 52 consecutive patients with AE-IPF who underwent autopsies at five university hospitals and one municipal hospital between 1999 and 2013. The following variables were abstracted from the medical records: demographic and clinical data, autopsy findings and complications during the clinical course until death.Results: The median age at autopsy was 71 years (range 47-86 years), and the subjects included 38 (73.1%) males. High-dose corticosteroid therapy was initiated in 45 (86.5%) patients after AE-IPF. The underling fibrotic lesion was classified as having the usual interstitial pneumonia (UIP) pattern in all cases. Furthermore, 41 (78.8%) patients had diffuse alveolar damage (DAD), 15 (28.8%) exhibited pulmonary hemorrhage, nine (17.3%) developed pulmonary thromboembolism and six (11.5%) were diagnosed with lung carcinoma. In addition, six (11.5%) patients developed pneumothorax prior to death and 26 (53.1%) developed diabetes that required insulin treatment after the administration of high-dose corticosteroid therapy. In addition, 15 (28.8%) patients presented with bronchopneumonia during their clinical course and/or until death, including fungal (seven, 13.5%), cytomegalovirus (six, 11.5%) and bacterial (five, 9.6%) infections.Conclusions: The pathological findings in patients with AE-IPF represent not only DAD, but also a variety of pathological conditions. Therefore, making a diagnosis of AE-IPF is often difficult, and the use of cautious diagnostic approaches is required for appropriate treatment.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Respiratory Research, 15(1), 109; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"25176016","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12931-014-0109-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Oda et al.; licensee BioMed Central Ltd."},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14659921","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oda, Keishi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishimoto, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Sohsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kushima, Hisako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imanaga, Tomotoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Tatsuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishimatsu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Nobuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naito, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yatera, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakazato, Masamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Jun-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mukae, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ResRes15_109.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ResRes15_109.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5731/files/ResRes15_109.pdf"},"version_id":"bcb87169-e402-44e4-b075-ef65776b7314"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-21"},"publish_date":"2014-10-21","publish_status":"0","recid":"5731","relation_version_is_last":true,"title":["Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:59:42.486728+00:00"}