{"created":"2023-05-15T16:33:28.966109+00:00","id":5733,"links":{},"metadata":{"_buckets":{"deposit":"7d2b8c9d-4d4e-49ec-8bbc-c64f9f5ee850"},"_deposit":{"created_by":2,"id":"5733","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5733"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005733","sets":["73:74"]},"author_link":["24647","24646"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-28","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"555","bibliographicPageStart":"542","bibliographicVolumeNumber":"190","bibliographic_titles":[{"bibliographic_title":"Journal of Controlled Release"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"For safe and effective therapy, drugs should be delivered selectively to their target tissues or cells at an optimal rate. Drug delivery system technology maximizes the therapeutic efficacy and minimizes unfavorable drug actions by controlling their distribution profiles. Ligand-receptor binding is a typical example of specific recognition mechanisms in the body; therefore, ligand-modified drug carriers have been developed for active targeting based on receptor-mediated endocytosis. Among the various ligands reported thus far, sugar recognition is a promising approach for active targeting because of their high affinity and expression. Glycosylation has been applied for both macromolecular and liposomal carriers for cell-selective drug targeting. Recently, the combination of ultrasound exposure and glycosylated bubble liposomes has been developed. In this review, recent advances of glycosylation-mediated targeted drug delivery systems are discussed.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Controlled Release, 190, pp.542-555; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jconrel.2014.06.001","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Elsevier B.V. All rights reserved."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Controlled Release. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Controlled Release, 190, (2014)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01683659","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawakami, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashida, Mitsuru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JCR190_542.pdf","filesize":[{"value":"511.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCR190_542.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5733/files/JCR190_542.pdf"},"version_id":"b916ada9-0002-467f-86e9-7f6c1a21893c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Drug delivery","subitem_subject_scheme":"Other"},{"subitem_subject":"Glycosylation","subitem_subject_scheme":"Other"},{"subitem_subject":"Liposomes","subitem_subject_scheme":"Other"},{"subitem_subject":"Macromolecular carriers","subitem_subject_scheme":"Other"},{"subitem_subject":"Targeting","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Glycosylation-mediated targeting of carriers","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glycosylation-mediated targeting of carriers"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-22"},"publish_date":"2014-10-22","publish_status":"0","recid":"5733","relation_version_is_last":true,"title":["Glycosylation-mediated targeting of carriers"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:59:39.344227+00:00"}