{"created":"2023-05-15T16:33:33.911024+00:00","id":5845,"links":{},"metadata":{"_buckets":{"deposit":"a6b02dd6-60d2-45bc-8c8d-5a3f978493b8"},"_deposit":{"created_by":2,"id":"5845","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5845"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005845","sets":["29:30"]},"author_link":["25069","25068","25072","25074","25075","25077","25067","25078","25082","25081","25073","25080","25079","25070","25071","25076"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"717","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"BMC Cancer"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: There is currently no consensus on the correlations between androgen concentrations in prostate tissue and blood and stage and pathological grade of prostate cancer. In this study, we used a newly-developed ultra-sensitive liquid-chromatography tandem mass spectrometry method to measure testosterone (T) and dihydrotestosterone (DHT) concentrations in blood and needle biopsy prostate specimens from patients with prostate cancer.Methods: We analyzed androgen levels in 196 men diagnosed with prostate cancer. All patients had undergone systematic needle biopsy, and an additional needle biopsy from the peripheral zone was conducted for the simultaneous determination of T and DHT. We analyzed the relationships between T and DHT levels in tissue and blood and Gleason score, clinical stage, and percentage of positive biopsy cores, using multivariate analysis. Results: The median T and DHT levels in blood were 3551.0 pg/mL and 330.5 pg/mL, respectively. There was a strong correlation between serum T and DHT. The median T and DHT levels in prostate tissue were 0.5667 pg/mg and 7.0625 pg/mg, respectively. In multivariate analysis, serum prostate-specific antigen and tissue T levels were significantly associated with poor prognosis; high T levels in prostate tissue were significantly related to high Gleason score (p = 0.041), advanced clinical stage (p = 0.002), and a high percentage of positive biopsy cores (p = 0.001). Conclusions: The results of this study indicate that high T levels in prostate tissue are related to high Gleason score, advanced clinical stage, and a high percentage of positive biopsy cores in patients with prostate cancer. T level in needle biopsy specimens may therefore be a useful prognostic factor in prostate cancer patients.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BMC Cancer, 14(1), 717; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1471-2407-14-717","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Miyoshi et al.; licensee BioMed Central Ltd."},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14712407","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyoshi, Yasuhide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uemura, Hiroji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umemoto, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamaki, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masumori, Naoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichikawa, Tomohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizokami, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimura, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonomura, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, Seijiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Masaoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubota, Yoshinobu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BMCCan14_717.pdf","filesize":[{"value":"196.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCCan14_717.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5845/files/BMCCan14_717.pdf"},"version_id":"b88ec57a-4cc8-4fc5-a32e-472b36d62af4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Androgen","subitem_subject_scheme":"Other"},{"subitem_subject":"Dihydrotestosterone","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostate cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Testosterone","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-10"},"publish_date":"2014-12-10","publish_status":"0","recid":"5845","relation_version_is_last":true,"title":["High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:57:53.112702+00:00"}