{"created":"2023-05-15T16:29:43.712261+00:00","id":589,"links":{},"metadata":{"_buckets":{"deposit":"af6a251d-9c62-4e80-8806-d84b8ef7b328"},"_deposit":{"created_by":2,"id":"589","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"589"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000589","sets":["35:36"]},"author_link":["3035","3039","3031","3036","3037","3040","3034","3033","3038","3032"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"104264","bibliographicVolumeNumber":"81","bibliographic_titles":[{"bibliographic_title":"Infection, Genetics and Evolution"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Influenza virus B belongs to the family Orthomyxoviridae with segmented negative-sense RNA genomes. Since 1970s, influenza B has diverged intoVictoria and Yamagata, which differs in antigenic and evolutionary characteristics. Yet, molecular-epidemiological information of influenza B from developing nations is limited. In central Vietnam, influenza A subtype-specific circulation pattern and clinical characteristics were previously described. However, molecular evolutionary characteristics of influenza B has not been discussed to date. We utilized the influenza B positives obtained from paediatric ARI surveillance during 2007?2013. Influenza B HA and NA genes were amplified, sequenced, and phylogenetic/molecular evolutionary analysis was performed using Maximum Likelihood and Bayesian MCMC. Phylodynamics analysis was performed with Bayesian Skyline Plot (BSP). Furthermore, we performed selection pressure analysis and estimated N-glycosylation sites. In the current study, overall positive rate for influenza B was 3.0%, and Victoria lineage immediately became predominant in post-A/H1N1pdm09 period. The noticeable shift in Victoria lineage WHO Group occurred. With respect to the evolutionary rate (substitutions/site/year), Victoria lineage HA gene was evolving faster than Yamagata lineage (2.43 × 10?3 vs 2.00 × 10?3). Furthermore, the evolutionary rate of Victoria Group 5 was greater than Group 1. BSP presented the rapid growth in Effective Population Size (EPS) of Victoria lineage occurred soon after the 1st A/H1N1pdm09 case was detected whereas the EPS of Yamagata lineage was stable for both genes. N-glycosylation pattern between lineages and among WHO Groups were slightly different, and HA gene had a total of 6 amino acid substitutions under positive section pressure (4 for Victoria and 2 for Yamagata). The current results highlight the importance of Victoria lineage in post-A/H1N1pdm09 period. Difference in evolutionary characteristics and phylodynamics may indicate lineage and WHO Group-specific evolutionary dynamics. It is necessary to further continue the molecular-epidemiological surveillance in local setting to gain a better understanding of local evolutionary characteristics of influenza B strains.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Infection, Genetics and Evolution, 81, art.no.104264; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.meegid.2020.104264","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15671348","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshihara, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minh, Le Nhat"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toizumi, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nguyen, Hien Anh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Vo, Hien Minh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashizume, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dang, Duc Anh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Lay-Myint"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"IGE81_104264.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IGE81_104264.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/589/files/IGE81_104264.pdf"},"version_id":"eb4ad2ac-c444-4204-8430-84c5a725bf39"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ARI","subitem_subject_scheme":"Other"},{"subitem_subject":"Influenza B","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular evolution","subitem_subject_scheme":"Other"},{"subitem_subject":"Paediatric infectious disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Phylogenetic","subitem_subject_scheme":"Other"},{"subitem_subject":"Vietnam","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evolutionary dynamics of influenza B strains detected from paediatric acute respiratory infections in central Vietnam","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evolutionary dynamics of influenza B strains detected from paediatric acute respiratory infections in central Vietnam"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-30"},"publish_date":"2020-03-30","publish_status":"0","recid":"589","relation_version_is_last":true,"title":["Evolutionary dynamics of influenza B strains detected from paediatric acute respiratory infections in central Vietnam"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:14:55.807982+00:00"}