{"created":"2023-05-15T16:33:37.732081+00:00","id":5934,"links":{},"metadata":{"_buckets":{"deposit":"367b74c6-ed5c-43d4-a35f-3340f3365d7a"},"_deposit":{"created_by":2,"id":"5934","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5934"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005934","sets":["52:56"]},"author_link":["25732","25731","25730","25733","25729","25734"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53","bibliographicPageStart":"43","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"The Journal of Toxicological Sciences"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nonylphenol ethoxylate (NPE) is a non-ionic surfactant, that is degraded to short-chain NPE and 4-nonylphenol (NP) by bacteria in the environment. NP, one of the most common environmental endocrine disruptors, exhibits weak estrogen-like activity. In this study, we investigated whether oral administration of NP (at 0.5 and 5 mg/kg doses) affects spatial learning and memory, general activity, emotionality, and fear-motivated learning and memory in male and female Sprague-Dawley (SD) rats. SD rats of both sexes were evaluated using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) that was used to assess spatial learning and memory. In the MAZE test, the time required to reach the reward in male rats treated with 0.5 mg/kg NP group and female rats administered 5 mg/kg NP was significantly longer than that for control animals of the corresponding sex. In other behavioral tests, no significant differences were observed between the control group and either of the NP-treated groups of male rats. In female rats, inner and ambulation values for animals administered 0.5 mg/kg NP were significantly higher than those measured in control animals in open-field test, while the latency in the group treated with 5 mg/kg NP was significantly shorter compared to the control group in step-through passive avoidance test. This study indicates that oral administration of a low-dose of NP slightly impairs spatial learning and memory performance in male and female rats, and alters emotionality and fear-motivated learning and memory in female rats only","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Journal of Toxicological Sciences, 40(1), pp.43-53; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本毒性学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2131/jts.40.43","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 The Japanese Society of Toxicology"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03881350","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18803989","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society of Toxicology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawaguchi, Shinichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwahara, Rika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohara, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Yutaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oku, Yushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Kimihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JTS40_43.pdf","filesize":[{"value":"662.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JTS40_43.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5934/files/JTS40_43.pdf"},"version_id":"fc199886-d96d-4238-b1a8-7245ab750907"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Behavior","subitem_subject_scheme":"Other"},{"subitem_subject":"Central nervous system","subitem_subject_scheme":"Other"},{"subitem_subject":"Endocrine disruptors","subitem_subject_scheme":"Other"},{"subitem_subject":"Learning and memory","subitem_subject_scheme":"Other"},{"subitem_subject":"Nonylphenol","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats"}]},"item_type_id":"2","owner":"2","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-23"},"publish_date":"2015-01-23","publish_status":"0","recid":"5934","relation_version_is_last":true,"title":["Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:56:00.419497+00:00"}