{"created":"2023-05-15T16:33:38.265153+00:00","id":5947,"links":{},"metadata":{"_buckets":{"deposit":"9b7c4c3c-3d69-463b-be3a-ec58369f3846"},"_deposit":{"created_by":2,"id":"5947","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"5947"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00005947","sets":["29:68:69:361"]},"author_link":["25851","25854","25846","25843","25850","25857","25853","25844","25852","25845","25848","25849","25858","25856","25855","25847"],"item_3_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Comparison of efficacy of human cell-derived and yeast-derived recombinant hepatitis B vaccines"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"27","bibliographicPageStart":"21","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"保健学研究"},{"bibliographic_title":"Health Science Research","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2000 ～ 2013年度に入学した長崎大学看護学生1,000名のHBs抗原とHBs抗体を検査した．HBs抗原陽性率は0.10％（2000 ～ 2004年0.27％，2005 ～ 2013年0.0％），HBs抗体陽性率は1.80％（2000 ～ 2004年1.08％，2005 ～ 2013年2.22％）だった．HBs抗原・HBs抗体とも陰性だった970名に対しヒト培養細胞由来遺伝子組換え沈降 B 型肝炎ワクチン「明乳」（Mワクチン）または酵母由来遺伝子組換え沈降 B 型肝炎ワクチン「ビームゲン」（B ワクチン）を接種した．ワクチン接種後のHBs抗体獲得率は，Mワクチン接種者（n=563）98.0％，B ワクチン接種者（n=407）99.0％と変わりないが，HBs抗体価中央値は，2120.0mIU/mL，313.0mIU/mLとMワクチン接種者が有意差に高かった．HBs抗体価は経年的に低下し，ワクチン接種後の抗体価が低い者はより早期に陰性となった．すなわち，HBs抗体陽性持続期間はMワクチン接種者が B 接種者より長かった．","subitem_description_type":"Abstract"},{"subitem_description":"A total of 1,000 nursing students of Nagasaki University School of Health Sciences were examined for serum HBsAg and anti-HBs at their first year between 2000 and 2013. The prevalence of HBsAg was 0.10％; 0.27％ in 2000-2004 and 0.0％ in 2005-2013. The prevalence of anti-HBs was 1.80％; 1.08 ％ in 2000-2004 and 2.22％ in 2005-2013. A total of 970 students who were negative for HBsAg and anti-HBs received a primary series of hepatitis B vaccinations with human cell-derived recombinant vaccines （Meinyu） or yeast-derived recombinant vaccines （Bimmugen）. Subsequently, 98.0％ by Meinyu （n=563）and 99.0％ by Bimmugen（ n=407） acquired anti-HBs titers over 10 mIU/mL. The median titers of anti-HBs in Meinyu recipients（ 2120.0 mIU/mL） were significantly higher than those in Bimmugen recipients\n（313.0 mIU/mL）. The anti-HBs titers were declined with time following vaccination, and the decline seemed to depend on the titer originally obtained. Thus, Meinyu recipients may have more persistence of anti-HBs titers over 10 mIU/mL than Bimmugen recipients.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"保健学研究, 27, pp.21-27; 2015","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"25851","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tashiro, Takayoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"25852","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanaka, Chiaki"}]},{"nameIdentifiers":[{"nameIdentifier":"25853","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hikita, Keiko"}]},{"nameIdentifiers":[{"nameIdentifier":"25854","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ogata, Yui"}]},{"nameIdentifiers":[{"nameIdentifier":"25855","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishizaki, Hitomi"}]},{"nameIdentifiers":[{"nameIdentifier":"25856","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tashiro, Masato"}]},{"nameIdentifiers":[{"nameIdentifier":"25857","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ishimatsu, Yuji"}]},{"nameIdentifiers":[{"nameIdentifier":"25858","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Izumikawa, Koichi"}]}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎大学大学院医歯薬学総合研究科保健学専攻"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12200909","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18814441","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Master Course of Health Sciences Graduate School of Biomedical Sciences Nagasaki University"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田代, 隆良"}],"nameIdentifiers":[{"nameIdentifier":"25843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 千明"}],"nameIdentifiers":[{"nameIdentifier":"25844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"疋田, 桂子"}],"nameIdentifiers":[{"nameIdentifier":"25845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"緒方, 優衣"}],"nameIdentifiers":[{"nameIdentifier":"25846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西崎, 仁美"}],"nameIdentifiers":[{"nameIdentifier":"25847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田代, 将人"}],"nameIdentifiers":[{"nameIdentifier":"25848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石松, 祐二"}],"nameIdentifiers":[{"nameIdentifier":"25849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"泉川, 公一"}],"nameIdentifiers":[{"nameIdentifier":"25850","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"hokenn27_21.pdf","filesize":[{"value":"464.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"hokenn27_21.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/5947/files/hokenn27_21.pdf"},"version_id":"72766d4f-5708-4d33-af4f-187cd4450a07"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"B 型肝炎ワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"HBs抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"HBs抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"看護学生","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatitis B vaccine","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-HBs","subitem_subject_scheme":"Other"},{"subitem_subject":"HBsAg","subitem_subject_scheme":"Other"},{"subitem_subject":"Nursing students","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較"}]},"item_type_id":"3","owner":"2","path":["361"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-23"},"publish_date":"2015-01-23","publish_status":"0","recid":"5947","relation_version_is_last":true,"title":["ヒト培養細胞由来と酵母由来遺伝子組換えB型肝炎ワクチンの効果の比較"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:55:39.920613+00:00"}