{"created":"2023-05-15T16:29:44.140691+00:00","id":599,"links":{},"metadata":{"_buckets":{"deposit":"a9171d72-8b47-446c-8b28-6c8afdb31882"},"_deposit":{"created_by":2,"id":"599","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"599"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000599","sets":["50:51"]},"author_link":["112164","112162","112166","112163","112165","112168","112167"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"61","bibliographicPageStart":"54","bibliographicVolumeNumber":"171","bibliographic_titles":[{"bibliographic_title":"Toxicon"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We tested whether tetrodotoxin (TTX) functions as a stress relieving substance in puffer fish. We orally administered TTX to the juveniles of hatchery-reared non-toxic tiger puffer Takifugu rubripes and measured the effects of TTX on brain corticotropin-releasing hormone (CRH) mRNA expression and plasma cortisol levels in comparison with effects in non-toxic juveniles. Firstly, the reciprocal connections of CRH and adrenocorticotropic hormone (ACTH) were confirmed by dual-label immunohistochemistry. CRH-immunoreactive (ir) cell bodies were detected in the hypothalamus and CRH-ir fibers were observed to project to ACTH-ir cells in the rostral pars distalis of the pituitary. Next, a TTX-containing diet (2.35 mouse units (517?ng)/g diet) or a non-toxic diet were fed to the fish for 28 days under a recirculating system. Standard length and body weight became significantly larger in the TTX-treated group. The degree of loss of the caudal fin, which is an indicator of the degree of agonistic interactions, where high values show a higher loss of caudal fin of a fish due to nipping by other individuals, was significantly lower in the TTX-treated group. Relative CRH mRNA expression levels in the brain and cortisol levels in the plasma were significantly lower in the TTX-treated group. These results indicate that TTX functions as a stress relieving substance by affecting the CRH-ACTH-cortisol axis and reducing agonistic interactions in tiger puffer juveniles.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Toxicon, 171, pp.54-61; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.toxicon.2019.09.024","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00410101","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Amano, Masafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amiya, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaoka, Minami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatani, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arakawa, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakakura, Yoshitaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-25"}],"displaytype":"detail","filename":"Toxicon171_54.pdf","filesize":[{"value":"601.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Toxicon171_54.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/599/files/Toxicon171_54.pdf"},"version_id":"e9f7f095-1620-493f-bc33-39052e8fab30"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TTX","subitem_subject_scheme":"Other"},{"subitem_subject":"CRH","subitem_subject_scheme":"Other"},{"subitem_subject":"ACTH","subitem_subject_scheme":"Other"},{"subitem_subject":"Cortisol","subitem_subject_scheme":"Other"},{"subitem_subject":"Stress","subitem_subject_scheme":"Other"},{"subitem_subject":"Tiger puffer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes"}]},"item_type_id":"2","owner":"2","path":["51"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-30"},"publish_date":"2020-09-30","publish_status":"0","recid":"599","relation_version_is_last":true,"title":["Tetrodotoxin functions as a stress relieving substance in juvenile tiger puffer Takifugu rubripes"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T23:01:31.768885+00:00"}