{"created":"2023-05-15T16:33:40.947024+00:00","id":6010,"links":{},"metadata":{"_buckets":{"deposit":"71322fdb-d72d-41db-b5bb-bf1efa937a9f"},"_deposit":{"created_by":2,"id":"6010","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6010"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006010","sets":["25:26"]},"author_link":["26267","26272","26268","26265","26269","26263","26270","26271","26273","26282","26266","26275","26264","26277","26278","26274","26281","26279","26280","26276"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Successful treatment with a combination of lenalidomide and dexamethasone for cryoglobulinemia associated with multiple myeloma"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"957","bibliographicPageStart":"953","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"臨床血液"},{"bibliographic_title":"The Japanese Journal of Clinical Hematology","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"クリオグロブリン血症(Cg)を合併した多発性骨髄腫(MM)に対する標準治療は確立していない。今回レナリドミドとデキサメサゾンの併用療法（Ld療法）が有効であった症例を経験した。症例は76歳，女性。主訴は右踵部の皮膚潰瘍，四肢の疼痛としびれであった。20年前にCg併発MMと診断された。以降MMに対しては従来の抗癌剤治療，そしてCg関連症状に対しては血漿交換療法など行われていたが，Cg関連症状のコントロールが困難となり治療目的で入院となった。入院後，血漿交換療法を施行し血清クリオグロブリン値は減少したが，皮膚症状の改善は認めなかった。Ld療法を開始後，血清M蛋白とクリオグロブリン値の減少とともに皮膚潰瘍，しびれ，そして疼痛も軽快した。","subitem_description_type":"Abstract"},{"subitem_description":"Cryoglobulinemia (Cg) in multiple myeloma (MM) is rare and no standard treatment has yet been established. Herein, we report a case of MM with Cg, successfully treated with a combination of lenalidomide and dexamethasone. A 76-year-old woman suffering from skin ulcerations, extremity pain and peripheral neuropathy was diagnosed as having IgG-kappa MM with Cg in 1992. She intermittently received conventional chemotherapy, immunosuppressant therapy and plasma exchange. Despite these treatments, Cg-related symptoms eventually became uncontrollable. She was admitted to our hospital in 2012 because of worsening skin symptoms involving both ankles. Plasmapheresis proved ineffective. Improvement of skin ulcerations and numbness was achieved with administration of lenalidomide at 25 mg daily with weekly dexamethasone, which also decreased the cryoglobulin level. The course of this patient suggests that lenalidomide plus dexamethasone is a promising treatment for MM with Cg.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"臨床血液, 55(8), pp.953-957; 2014","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26273","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Taniguchi, Hiroaki"}]},{"nameIdentifiers":[{"nameIdentifier":"26274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imaizumi, Yoshitaka"}]},{"nameIdentifiers":[{"nameIdentifier":"26275","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Makiyama, Junya"}]},{"nameIdentifiers":[{"nameIdentifier":"26276","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ando, Koji"}]},{"nameIdentifiers":[{"nameIdentifier":"26277","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sawayama, Yasushi"}]},{"nameIdentifiers":[{"nameIdentifier":"26278","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imanishi, Daisuke"}]},{"nameIdentifiers":[{"nameIdentifier":"26279","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Taguchi, Jun"}]},{"nameIdentifiers":[{"nameIdentifier":"26280","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsushima, Hideki"}]},{"nameIdentifiers":[{"nameIdentifier":"26281","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hata, Tomoko"}]},{"nameIdentifiers":[{"nameIdentifier":"26282","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Miyazaki, Yasushi"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本血液学会"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"25186485","subitem_relation_type_select":"PMID"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 一般社団法人 日本血液学会"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04851439","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japanese Society of Hematology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷口, 広明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今泉, 芳孝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"牧山, 純也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安東, 恒史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤山, 靖"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今西, 大介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田口, 潤"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"対馬, 秀樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"波多, 智子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮﨑, 泰司"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"RinKetsu55_953.pdf","filesize":[{"value":"851.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RinKetsu55_953.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6010/files/RinKetsu55_953.pdf"},"version_id":"0341c09d-d351-4f79-864a-a0018ea05348"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cryoglobulinemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Cryoglobulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Multiple myeloma","subitem_subject_scheme":"Other"},{"subitem_subject":"Lenalidomide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"クリオグロブリン血症に対してレナリドミド・デキサメサゾン併用療法が有効であった多発性骨髄腫","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クリオグロブリン血症に対してレナリドミド・デキサメサゾン併用療法が有効であった多発性骨髄腫"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-02"},"publish_date":"2015-03-02","publish_status":"0","recid":"6010","relation_version_is_last":true,"title":["クリオグロブリン血症に対してレナリドミド・デキサメサゾン併用療法が有効であった多発性骨髄腫"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:31:39.817618+00:00"}