{"created":"2023-05-15T16:33:41.545570+00:00","id":6024,"links":{},"metadata":{"_buckets":{"deposit":"328ec42a-19d2-4e06-aaf7-a134c43a7e05"},"_deposit":{"created_by":2,"id":"6024","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6024"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006024","sets":["52:56"]},"author_link":["26369","26373","26372","26370","26371"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"46","bibliographicPageStart":"40","bibliographicVolumeNumber":"130","bibliographic_titles":[{"bibliographic_title":"Physiology & Behavior"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10. mg/kg/day) or vehicle (1. ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and step-through passive avoidance tests. MAZE test is an appetite-motivation test, and we used this mainly for assessing spatial learning and memory. In the MAZE test, GEN groups exhibited shorter latency from start to goal than the vehicle-treated group in both sexes. On the other hand, performances in the step-through passive avoidance test were non-monotonically inhibited by GEN in both sexes, and a significant difference was observed in low dose of the GEN-treated group compared to the vehicle-treated group in female rats. Furthermore, we found that perinatal exposure to GEN did not significantly alter locomotor activity or emotionality as assessed by the open-field and elevated-plus maze tests. These results suggest that perinatal exposure to GEN improved spatial learning and memory of rat offspring, but impaired their passive avoidance learning and memory.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Physiology & Behavior, 130, pp.40-46; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.physbeh.2014.03.006","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Elsevier Inc."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in Physiology & Behavior. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Physiology & Behavior, 130,  (2014)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00319384","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kohara, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwahara, Rika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawaguchi, Shinichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jojima, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Kimihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"PhyBe130_40.pdf","filesize":[{"value":"308.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PhyBe130_40.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6024/files/PhyBe130_40.pdf"},"version_id":"db1cf4bf-a660-4793-b6f1-58293d54872a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Behavior","subitem_subject_scheme":"Other"},{"subitem_subject":"Central nervous system","subitem_subject_scheme":"Other"},{"subitem_subject":"Genistein","subitem_subject_scheme":"Other"},{"subitem_subject":"Isoflavone","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-monotonic dose response","subitem_subject_scheme":"Other"},{"subitem_subject":"Perinatal exposure","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring"}]},"item_type_id":"2","owner":"2","path":["56"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-18"},"publish_date":"2015-03-18","publish_status":"0","recid":"6024","relation_version_is_last":true,"title":["Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:53:36.985228+00:00"}