{"created":"2023-05-15T16:33:44.374180+00:00","id":6091,"links":{},"metadata":{"_buckets":{"deposit":"2a78d68b-fe9f-4177-b9cc-a57a7068827a"},"_deposit":{"created_by":2,"id":"6091","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6091"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006091","sets":["35:36"]},"author_link":["26518","26520","26521","26517","26514","26519","26522","26515","26516"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"215","bibliographicPageStart":"207","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Infectious Diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although IFN-γ release assays (IγRAs) provide increased specificity over tuberculin skin tests, the early and sensitive detection of reactivation of latently infected Mycobacterium tuberculosis is required to control tuberculosis (TB). Recently, a multicolor flow cytometry has been developed to study CD4+ T cell cytokine responses (IFN-γ/IL-2/TNF-a) to purified protein derivatives (PPD) and M. tuberculosis-specific antigens (ESAT-6/CFP-10) and provided useful information regarding anti-TB immunity. However, the diagnostic relevancy remains uncertain. Here, we analyzed three additional CD4+ T cell cytokine responses (IL-10/IL-13/IL-17) to latent mycobacterial antigens (a-crystallin, methylated heparin-binding hemagglutinin [HBHA], and mycobacterial DNA-binding protein 1 [MDP-1]) as well as PPD and ESAT-6/CFP-10 in 12 IGRA+ TB cases and 8 healthy controls. No significant difference in IFN-γ response was observed between TB cases and controls, which was likely due to the high variation among the individuals. However, we found a significant increase over healthy controls in (i) the IL-2 response to HBHA in recovery stage TB cases, (ii) the number of M. tuberculosisspecific polyfunctional CD4+ T cells in on-treatment and recovery stage cases, and (iii) the IL-17 response to HBHA and MDP-1 in on-treatment and recovery stage cases. These results suggest that a combination of these T cell cytokine parameters could aid in accurate diagnosis of latent TB infection.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Japanese Journal of Infectious Diseases, 66(3), pp.207-215; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"国立感染症研究所"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.7883/yoken.66.207","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13446304","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"National Institute of Infectious Diseases"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamashita, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hoshino, Yoshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oka, Mayuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Sokichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ariga, Haruyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makino, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ariyoshi, Koya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsunetsugu-Yokota, Yasuko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JID66_207.pdf","filesize":[{"value":"923.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JID66_207.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6091/files/JID66_207.pdf"},"version_id":"a7d48293-44a1-47aa-a7a6-1d1abaf3b358"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tuberculosis","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell cytokine response","subitem_subject_scheme":"Other"},{"subitem_subject":"latent infection","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-07-30"},"publish_date":"2013-07-30","publish_status":"0","recid":"6091","relation_version_is_last":true,"title":["Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:52:11.764508+00:00"}