{"created":"2023-05-15T16:29:45.049165+00:00","id":620,"links":{},"metadata":{"_buckets":{"deposit":"18dd8e79-f0e3-4125-bcdd-ee76f7ce39be"},"_deposit":{"created_by":2,"id":"620","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"620"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000620","sets":["10:11"]},"author_link":["3135","3136","3137","3139","3138","3142","3140","3144","3141","3143"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"4656","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (the principal mediators of atherosclerosis). Despite this, aggressive endothelial repair (progressing atherosclerosis) might cause a wasting reduction in CD34+ cells, which could result in a lower capacity of endothelial repair and hypertension. As yet, no prospective study has clarified the association of circulating CD34+ cells with active arterial wall thickening. We conducted a prospective study of 363 men aged 60?69 years who participated in a general health check-up at least twice from 2014?2017. The circulating CD34+ cell count was significantly positively associated with active arterial wall thickening among subjects without hypertension (n = 236), but not among subjects with hypertension (n = 127). The fully adjusted odds ratios (ORs) of active arterial wall thickening for the logarithmic circulating CD34+ cell count were 1.83 (1.19, 2.84) and 0.69 (0.36, 1.32) for subjects without and with hypertension, respectively. Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension. This study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 10(1), art.no.4656; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-020-61475-4","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyoura, Kairi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyamatsu, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukui, Shoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamai, Mami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nobusue, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanashi, Hirotomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"SciRep10_4656.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep10_4656.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/620/files/SciRep10_4656.pdf"},"version_id":"91ccae1f-3cad-464a-b244-5c134cd9eee4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-08"},"publish_date":"2020-04-08","publish_status":"0","recid":"620","relation_version_is_last":true,"title":["Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:14:44.654713+00:00"}