{"created":"2023-05-15T16:29:45.307893+00:00","id":626,"links":{},"metadata":{"_buckets":{"deposit":"1fc32949-6985-41ea-80ca-15ec9e9e88ac"},"_deposit":{"created_by":2,"id":"626","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"626"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000626","sets":["10:11"]},"author_link":["3175","3177","3176","3179","3178"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicPageEnd":"9735","bibliographicPageStart":"9730","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"RSC Advances"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"+)-5-Thiosucrose 1, a novel isosteric sulfur analog of sucrose, was synthesized stereoselectively for the first time via indirect β-d-fructofuranosidation involving selective β-d-psicofuranosidation, followed by stereo-inversion of the secondary hydroxy group at the C-3 position on the furanose ring. Glycosidation of protected 5-Thio-d-glucose with a d-psicofuranosyl donor provided β-d-psicofuranosyl 5-Thio-α-d-glucopyranoside and that with d-fructofuranosyl donor gave α-d-fructofuranosyl 5-Thio-α-d-glucopyranoside. Two anomeric stereocenters of the glycosyl donor and acceptor were controlled correctly to provide a single disaccharide among four possible anomeric isomers in the glycosylation. Conversion of the resulting disaccharides afforded (+)-5-Thiosucrose 1 and (+)-5-Thioisosucrose 2 in excellent yields, respectively. Inhibitory activities of 1 and 2 against α-glucosidase in vitro were also examined.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"RSC Advances, 10(16), pp.9730-9735; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Royal Society of Chemistry"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1039/D0RA01033B","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Royal Society of Chemistry. Open Access Article. Published on 06 March 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20462069","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueda, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pi, Jinhong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makura, Yui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uenishi, Jun'ichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"RSCA10_9730.pdf","filesize":[{"value":"778.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RSCA10_9730.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/626/files/RSCA10_9730.pdf"},"version_id":"d407e0c9-92af-45ad-91e6-aeeddbfa991a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Stereoselective synthesis of (+)-5-thiosucrose and (+)-5-thioisosucrose","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stereoselective synthesis of (+)-5-thiosucrose and (+)-5-thioisosucrose"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-09"},"publish_date":"2020-04-09","publish_status":"0","recid":"626","relation_version_is_last":true,"title":["Stereoselective synthesis of (+)-5-thiosucrose and (+)-5-thioisosucrose"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:14:35.087420+00:00"}