@article{oai:nagasaki-u.repo.nii.ac.jp:00006440,
 author = {Okita, Kogen and Takatani, Tomohiro and Nakayasu, Junichi and Yamazaki, Hideki and Sakiyama, Kazutaka and Ikeda, Koichi and Arakawa, Osamu and Sakakura, Yoshitaka},
 journal = {Toxicon},
 month = {Sep},
 note = {To reveal the accumulation profile of tetrodotoxin (TTX) in pufferfish Takifugu rubripes juveniles, we compared the localization of TTX in various tissues among wild juveniles and hatchery-reared juveniles with or without TTX administration using immunohistochemical technique with anti-TTX monoclonal antibody. Immuno-positive reaction was observed in hepatic tissue, basal cell of skin and olfactory, olfactory epithelium, optic nerve and brain (optic tectum, cerebellum, medulla oblongata) of wild juveniles (body length: BL, 4.7-9.4cm). TTX was detected in the same tissues as wild juveniles and epithelial cell layer of intestine of hatchery-reared juveniles (BL, 5.0-5.3cm) to which TTX was orally administrated. No positive reaction was observed from the tissues of hatchery-reared juveniles without TTX administration. These results suggest that orally administrated TTX to the non-toxic cultured juveniles is accumulated in the same manner of wild juveniles. In addition, our study revealed that pufferfish accumulates TTX in the central nervous system., Toxicon, 71, pp.128-133; 2013},
 pages = {128--133},
 title = {Comparison of the localization of tetrodotoxin between wild pufferfish Takifugu rubripes juveniles and hatchery-reared juveniles with tetrodotoxin administration},
 volume = {71},
 year = {2013}
}