@article{oai:nagasaki-u.repo.nii.ac.jp:00006479,
 author = {Hidaka, Masaaki and Takatsuki, Mitsuhisa and Okudaira, Sadayuki and Soyama, Akihiko and Muraoka, Izumi and Tanaka, Takayuki and Yamaguchi, Izumi and Hara, Takanobu and Miyaaki, Hisamitsu and Ichikawa, Tatsuki and Hayashi, Tomayoshi and Sakamoto, Ichiro and Nakao, Kazuhiko and Kuroki, Tamotsu and Kanematsu, Takashi and Eguchi, Susumu},
 issue = {2},
 journal = {Hepatology International},
 month = {Jun},
 note = {Purpose: The aim of this study is to evaluate the detectability of hepatocellular carcinoma (HCC) in the explanted cirrhotic liver using gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) and the degree of organic anion transporter OATP2/OATP8 (OATP1B1/1B3) HCC which could not be preoperatively detected by multi-detector computed tomography (MD-CT) and Gd-EOB-MRI. Methods: Eleven patients (HBV 3, HCV 7, nonBnonC 1) out of 145 recipients of liver transplantation were analyzed. The detectability by each imaging modality and the expression of OATP2/OATP8 of HCC were analyzed using the whole liver thin sliced histological and immunohistochemical examination retrospectively. Results: The imaging examination detected 17 lesions of HCC by MDCT and/or Gd-EOB-MRI. Only one lesion detected by Gd-EOB-MRI had well differentiated and minute (7 mm) HCC. However, the histological examination revealed newly 11 lesions and one false-positive lesion of HCC in the explanted livers. The median diameter of the preoperatively undetectable HCC by imaging was 8 mm (2-12). The histological characteristic of the preoperatively undetectable HCC was well differentiated HCC (10/11). The accuracy rate in MDCT and Gd-EOB-MRI was 53.6 % (15/28) and 57.1 % (16/28). The rate of positive predictive value in MDCT and Gd-EOB-MRI was 93.7 % (15/16) and 94.2 % (16/17), respectively. The expression of OATP2/OATP8 in the preoperatively undetectable HCC was negative in nine lesions, was weak positive in two lesions. Conclusions: The detectability of Gd-EOB-MRI is almost equal to MDCT in a cirrhotic liver. Small HCCs were difficult to detect even with Gd-EOB-MRI. The transporter of OATP2/OATP8 was less expressed in the preoperatively undetectable HCCs., Hepatology International, 7(2), pp.655-661; 2013},
 pages = {655--661},
 title = {The expression of transporter OATP2/OATP8 decreases in undetectable hepatocellular carcinoma by Gd-EOB-MRI in the explanted cirrhotic liver},
 volume = {7},
 year = {2013}
}