{"created":"2023-05-15T16:34:18.402143+00:00","id":6868,"links":{},"metadata":{"_buckets":{"deposit":"60fae95b-b75e-46fa-ada5-49d19710bea8"},"_deposit":{"created_by":2,"id":"6868","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6868"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006868","sets":["8:9"]},"author_link":["28746","28751","28739","28748","28753","28735","28740","28745","28734","28736","28742","28744","28756","28749","28741","28752","28743","28755","28747","28754","28750","28737","28738"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageStart":"e132","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Blood Cancer Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the peripheral blood leukocytes (PBLs) from the carriers of the human T-lymphotropic virus type-1 (HTLV-1) or the patients with adult T-cell leukemia (ATL), nuclear factor kappaB (NF-κB)-mediated antiapoptotic signals are constitutively activated primarily by the HTLV-1-encoded oncoprotein Tax. Tax interacts with the I κB kinase regulatory subunit NEMO (NF-κB essential modulator) to activate NF-κB, and this interaction is maintained in part by a molecular chaperone, heat-shock protein 90 (HSP90), and its co-chaperone cell division cycle 37 (CDC37). The antibiotic geldanamycin (GA) inhibits HSP90's ATP binding for its proper interaction with client proteins. Administration of a novel water-soluble and less toxic GA derivative, 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG), to Tax-expressing ATL-transformed cell lines, C8166 and MT4, induced significant degradation of Tax. 17-DMAG also facilitated growth arrest and cellular apoptosis to C8166 and MT4 and other ATL cell lines, although this treatment has no apparent effects on normal PBLs. 17-DMAG also downregulated Tax-mediated intracellular signals including the activation of NF-κB, activator protein 1 or HTLV-1 long terminal repeat in Tax-transfected HEK293 cells. Oral administration of 17-DMAG to ATL model mice xenografted with lymphomatous transgenic Lck-Tax (Lck proximal promoter-driven Tax transgene) cells or HTLV-1-producing tumor cells dramatically attenuated aggressive infiltration into multiple organs, inhibited de novo viral production and improved survival period. These observations identified 17-DMAG as a promising candidate for the prevention of ATL progression.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Blood Cancer Journal, 3(8), e132; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/bcj.2013.30","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 Macmillan Publishers Limited All rights reserved."},{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20445385","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikebe, Emi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawaguchi, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tezuka, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taguchi, S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirose, S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsui, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Senba, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishizono, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori, Mitsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueno, T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Yuetsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawa, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hall, William W."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minami, Yasufumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jeang, K. T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogata, Masao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morishita, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujisawa, J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iha, Hidekatsu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BCJ3_132.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BCJ3_132.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6868/files/BCJ3_132.pdf"},"version_id":"d123b382-03c7-47d6-b9f0-3ce0413469f3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"17-DMAG","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"ATL","subitem_subject_scheme":"Other"},{"subitem_subject":"Molecular chaperon","subitem_subject_scheme":"Other"},{"subitem_subject":"ransgenic model","subitem_subject_scheme":"Other"},{"subitem_subject":"Tax","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-10"},"publish_date":"2013-10-10","publish_status":"0","recid":"6868","relation_version_is_last":true,"title":["Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:36:51.512429+00:00"}