{"created":"2023-05-15T16:34:18.660495+00:00","id":6874,"links":{},"metadata":{"_buckets":{"deposit":"a8756aa0-48de-4b42-ae04-317e15fb7ac8"},"_deposit":{"created_by":2,"id":"6874","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6874"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006874","sets":["8:9"]},"author_link":["28801","28804","28803","28800","28802","28806","28808","28809","28805","28807"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1276","bibliographicPageStart":"1272","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"European Journal of Neurology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"European Journal of Neurology, 20(9), pp.1272-1276; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/ene.12169","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 EFNS."},{"subitem_rights":"The definitive version is available at wileyonlinelibrary.com."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13515101","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakata, Ruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motomura, Masakatsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokuda, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Taku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, Toshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsujihata, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"EJN20_1272.pdf","filesize":[{"value":"183.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EJN20_1272.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6874/files/EJN20_1272.pdf"},"version_id":"ae69cd54-0e70-4be1-9135-51429bb89b36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Associated autoimmune disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle-specific receptor tyrosine kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"Myasthenia gravis","subitem_subject_scheme":"Other"},{"subitem_subject":"Thymus","subitem_subject_scheme":"Other"},{"subitem_subject":"Titin antibodies","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-04-01"},"publish_date":"2014-04-01","publish_status":"0","recid":"6874","relation_version_is_last":true,"title":["Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:36:43.743868+00:00"}