{"created":"2023-05-15T16:34:22.509942+00:00","id":6947,"links":{},"metadata":{"_buckets":{"deposit":"be084253-48a0-4f47-bb0e-bdf06677c776"},"_deposit":{"created_by":2,"id":"6947","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6947"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006947","sets":["73:74"]},"author_link":["29297","29304","29301","29299","29296","29302","29303","29300","29298","29295"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-10-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"69","bibliographicPageStart":"61","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Cell Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To investigate the role of autophagy in Aβ pathology invivo, we crossed amyloid precursor protein (APP) transgenic mice with mice lacking autophagy in excitatory forebrain neurons obtained by conditional knockout of autophagy-related protein 7. Remarkably, autophagy deficiency drastically reduced extracellular Aβ plaque burden. This reduction of Aβ plaque load was due to inhibition of Aβ secretion, which led to aberrant intraneuronal Aβ accumulation in the perinuclear region. Moreover, autophagy-deficiency-induced neurodegeneration was exacerbated by amyloidosis, which together severely impaired memory. Our results establish a function for autophagy in Aβ metabolism: autophagy influences secretion of Aβ to the extracellular space and thereby directly affects Aβ plaque formation, a pathological hallmark of AD.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cell Reports, 5(1), pp.61-69; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.celrep.2013.08.042","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Authors. Published by Elsevier Inc. All rights reserved."},{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"22111247","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nilsson, Per"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Loganathan, Krishnapriya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekiguchi, Misaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuba, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hui, Kelvin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsubuki, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Motomasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Nobuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saido, Takaomi C."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"CelRep5_61.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CelRep5_61.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6947/files/CelRep5_61.pdf"},"version_id":"ed1f152b-e4ad-4c62-985f-c944b70f9964"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aβ Secretion and Plaque Formation Depend on Autophagy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aβ Secretion and Plaque Formation Depend on Autophagy"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-11-21"},"publish_date":"2013-11-21","publish_status":"0","recid":"6947","relation_version_is_last":true,"title":["Aβ Secretion and Plaque Formation Depend on Autophagy"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:35:21.384511+00:00"}