@article{oai:nagasaki-u.repo.nii.ac.jp:00006948,
 author = {Kusumoto, Saburo and Kawano, Hiroaki and Hayashi, Tomayoshi and Satoh, Osami and Yonekura, Tsuyoshi and Eguchi, Masamichi and Takeno, Masayoshi and Tsuneto, Akira and Koide, Yuji and Jo, Tatsuro and Maemura, Koji},
 issue = {20},
 journal = {Internal Medicine},
 month = {Oct},
 note = {A 31-year-old woman with primary mediastinal large B-cell lymphoma refractory to conventional chemotherapy was treated with high-dose chemotherapy containing cyclophosphamide (CY). Subsequently, she was treated with auto peripheral blood stem cell transplantation. Although a complete remission was obtained, heart failure developed two months later. Echocardiography showed an impaired systolic function with peri-cardial effusion. A biopsy of the endomyocardial region from the left ventricle demonstrated spotty myocar-dial hemorrhage and myocardial fibrosis with disruption and aggregation of mitochondrial cristae. Based on these findings, CY-induced cardiotoxicity was diagnosed. The patient was treated with conventional therapy for heart failure, which required approximately one year to improve her condition., Internal Medicine, 52(20), pp.2311-2315; 2013},
 pages = {2311--2315},
 title = {Cyclophosphamide-induced Cardiotoxicity with a Prolonged Clinical Course Diagnosed on an Endomyocardial Biopsy},
 volume = {52},
 year = {2013}
}