@article{oai:nagasaki-u.repo.nii.ac.jp:00006949,
 author = {Shida, Takayuki and Koseki, Hironobu and Yoda, Itaru and Horiuchi, Hidehiko and Sakoda, Hideyuki and Osaki, Makoto},
 journal = {International Journal of Nanomedicine},
 month = {Oct},
 note = {Bacterial adhesion to the surface of biomaterials is an essential step in the pathogenesis of implant-related infections. In this in vitro research, we evaluated the ability of Staphylococcus epidermidis to adhere to the surface of solid biomaterials, including oxidized zirconium-niobium alloy (Oxinium), cobalt-chromium-molybdenum alloy, titanium alloy, commercially pure titanium, and stainless steel, and performed a biomaterial-to-biomaterial comparison. The test specimens were physically analyzed to quantitatively determine the viable adherent density of the S. epidermidis strain RP62A (American Type Culture Collection [ATCC] 35984). Field emission scanning electron microscope and laser microscope examination revealed a featureless, smooth surface in all specimens (average roughness < 10 nm). The amounts of S. epidermidis that adhered to the biomaterial were significantly lower for Oxinium and the cobalt-chromium-molybdenum alloy than for commercially pure titanium. These results suggest that Oxinium and cobalt-chromium-molybdenum alloy are less susceptible to bacterial adherence and are less inclined to infection than other materials of a similar degree of smoothness., International Journal of Nanomedicine, 8, pp.3955-3961; 2013},
 pages = {3955--3961},
 title = {Adherence ability of Staphylococcus epidermidis on prosthetic biomaterials: an in vitro study},
 volume = {8},
 year = {2013}
}