@article{oai:nagasaki-u.repo.nii.ac.jp:00006954,
 author = {Yanamoto, Souichi and Yamada, Shin-ichi and Takahashi, Hidenori and Kawasaki, Goro and Ikeda, Hisazumi and Shiraishi, Takeshi and Fujita, Shuichi and Ikeda, Tohru and Asahina, Izumi and Umeda, Masahiro},
 issue = {4},
 journal = {Pathology & Oncology Research},
 month = {Oct},
 note = {Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate. The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3 % (6/58 patients) and 15.5 % (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7 %, which was significantly lower than that (96.2 %) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone., Pathology & Oncology Research, 19(4), pp.795-803; 2013},
 pages = {795--803},
 title = {Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients},
 volume = {19},
 year = {2013}
}