@article{oai:nagasaki-u.repo.nii.ac.jp:00006963,
 author = {Hayashida, Hideaki and Saito, Toshiyuki and Kawasaki, Koji and Kitamura, Masayasu and Furugen, Reiko and Iwasaki, Takahiro and Hayashida, Yoshiko and Nakazato, Mio and Sekita, Takaharu and Takamura, Noboru and Maeda, Takahiro},
 issue = {1},
 journal = {Atherosclerosis},
 month = {Jul},
 note = {Objective: Recent studies have suggested an association between periodontitis and atherosclerosis; however, the relationship between periodontal status and arterial alterations should be clarified. The purpose of this study was to examine associations between periodontal status and carotid intima-media thickness (cIMT) and arterial stiffness using the cardio-ankle vascular index (CAVI) in community dwellers. Methods: A community-based cross-sectional study of 1053 subjects ≥40 years with 10 teeth or more was conducted in Goto, Japan from 2008 to 2010. Results: In a multiple linear regression analysis adjusted for age, sex, number of present teeth, and other confounders, each 1-mm increase in mean periodontal pocket depth corresponded to a 0.02-mm increase in maximal cIMT (. β=0.018; P=0.049) and also to a 0.1 increase in mean CAVI (. β=0.133; P=0.040). In addition, each 1-mm increase in the mean periodontal attachment loss corresponded to a 0.01-mm increase in maximal cIMT (. β=0.013; P=0.040). A multiple logistic regression analysis revealed that each 1-mm increase in mean periodontal pocket depth was associated with an increased risk of a maximal cIMT >1mm (adjusted odds ratio [OR], 1.430; 95% confidence interval [CI], 1.067-1.918; P=0.017) and mean CAVI of ≥8 (OR, 1.323; 95% CI, 1.003-1.743; P=0.047). Furthermore, each 1-mm increase in mean periodontal attachment loss was associated with an increased risk of a maximal cIMT >1mm (OR, 1.251; 95% CI, 1.032-1.516; P=0.022). Conclusion: A linear, dose-dependent relationship was found between periodontal pocket depth, cIMT, and arterial stiffness., Atherosclerosis, 229(1), pp.186-191; 2013},
 pages = {186--191},
 title = {Association of periodontitis with carotid artery intima–media thickness and arterial stiffness in community-dwelling people in Japan: The Nagasaki Islands study},
 volume = {229},
 year = {2013}
}