@article{oai:nagasaki-u.repo.nii.ac.jp:00006973,
 author = {Seethorn, Nongluk and Wernsdorfer, Walther H. and Noedl, Harald and Karbwang, Juntra and Na-Bangchang, Kesara},
 issue = {4},
 journal = {American Journal of Tropical Medicine and Hygiene},
 month = {Oct},
 note = {The investigation of gender-specific partitioning of the antimalarial drug mefloquine to cellular and fluid blood compartments was performed using blood collected from a female and male healthy subject that were infected with Plasmodium falciparum PCM2 clone and spiked with mefloquine (0.25, 1, and 5 mM). Mefloquine concentrations in red cells of both female and male subjects were significantly higher than plasma, which suggests an intensive uptake by red cells. This was supported by a high ratio of mefloquine concentrations in the parasitized and non-parasitized red cells of about 4-fold. Gender-specific partitioning of mefloquine in parasitized blood was seen only in plasma where significantly higher concentrations were observed in female compared with male plasma. Down-adjusting the therapeutic dose of mefloquine in female patients with malaria is not advisable because mefloquine concentrations in the target cellular compartment are similar in both genders., American Journal of Tropical Medicine and Hygiene, 89(4), pp.737-741; 2013},
 pages = {737--741},
 title = {Investigation of the in vitro Gender-Specific Partitioning of Mefloquine in Malarial Infected Red Blood Cells and Plasma},
 volume = {89},
 year = {2013}
}