{"created":"2023-05-15T16:34:23.616591+00:00","id":6973,"links":{},"metadata":{"_buckets":{"deposit":"731424b4-5152-46f1-ae7d-568a5fd97eed"},"_deposit":{"created_by":2,"id":"6973","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6973"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006973","sets":["35:36"]},"author_link":["29451","29449","29448","29447","29450"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"741","bibliographicPageStart":"737","bibliographicVolumeNumber":"89","bibliographic_titles":[{"bibliographic_title":"American Journal of Tropical Medicine and Hygiene"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The investigation of gender-specific partitioning of the antimalarial drug mefloquine to cellular and fluid blood compartments was performed using blood collected from a female and male healthy subject that were infected with Plasmodium falciparum PCM2 clone and spiked with mefloquine (0.25, 1, and 5 mM). Mefloquine concentrations in red cells of both female and male subjects were significantly higher than plasma, which suggests an intensive uptake by red cells. This was supported by a high ratio of mefloquine concentrations in the parasitized and non-parasitized red cells of about 4-fold. Gender-specific partitioning of mefloquine in parasitized blood was seen only in plasma where significantly higher concentrations were observed in female compared with male plasma. Down-adjusting the therapeutic dose of mefloquine in female patients with malaria is not advisable because mefloquine concentrations in the target cellular compartment are similar in both genders.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"American Journal of Tropical Medicine and Hygiene, 89(4), pp.737-741; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society of Tropical Medicine and Hygiene"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4269/ajtmh.13-0328","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 by The American Society of Tropical Medicine and Hygiene"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00029637","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seethorn, Nongluk"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wernsdorfer, Walther H."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noedl, Harald"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Karbwang, Juntra"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Na-Bangchang, Kesara"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"AJTMH89_737.pdf","filesize":[{"value":"497.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AJTMH89_737.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6973/files/AJTMH89_737.pdf"},"version_id":"ba6aeb59-5461-473b-b2bf-5bb938743503"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Investigation of the in vitro Gender-Specific Partitioning of Mefloquine in Malarial Infected Red Blood Cells and Plasma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation of the in vitro Gender-Specific Partitioning of Mefloquine in Malarial Infected Red Blood Cells and Plasma"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-01"},"publish_date":"2014-11-01","publish_status":"0","recid":"6973","relation_version_is_last":true,"title":["Investigation of the in vitro Gender-Specific Partitioning of Mefloquine in Malarial Infected Red Blood Cells and Plasma"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:34:41.371680+00:00"}