{"created":"2023-05-15T16:34:24.594284+00:00","id":6996,"links":{},"metadata":{"_buckets":{"deposit":"60685127-8e94-42d5-a122-d99711c970cd"},"_deposit":{"created_by":2,"id":"6996","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"6996"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00006996","sets":["29:30"]},"author_link":["29584","29582","29588","29586","29583","29587","29589","29585"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"408","bibliographicPageStart":"401","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"The Journal of Physiological Sciences"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study examined mechanical and thermal hypersensitivity in the rat hind paw during cast immobilization of the hind limbs for 4 or 8 weeks and following cast removal. Blood flow, skin temperature, and volume of the rat hind paw were assessed in order to determine peripheral circulation of the hind limbs. Sensitization was analyzed by measuring the expression of the calcitonin gene-related peptide (CGRP) in the spinal dorsal horn following cast immobilization. Two weeks post immobilization, mechanical and thermal sensitivities increased significantly in all rats; however, peripheral circulation was not affected by immobilization. Cast immobilization for 8 weeks induced more serious hypersensitivity compared to cast immobilization for 4 weeks. Moreover, CGRP expression in the deeper lamina layer of the spinal dorsal horn increased in the rats immobilized for 8 weeks but not in those immobilized for 4 weeks. These findings suggest that immobilization-induced hypersensitivity develops during the immobilization period without affecting peripheral circulation. Our results also highlight the possibility that prolonged immobilization induces central sensitization in the spinal cord.","subitem_description_type":"Abstract"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The final publication is available at link.springer.com","subitem_description_type":"Other"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Journal of Physiological Sciences, 63(6), pp.401-408; 2013","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生理学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12576-013-0277-4","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Physiological Society of Japan and Springer Japan."},{"subitem_rights":"The original publication is available at link.springer.com"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18806546","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18806562","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Physiological Society of Japan"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hamaue, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Jiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekino, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chuganji, Sayaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Jyunya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, Toshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Origuchi, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okita, Minoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JPS63_401.pdf","filesize":[{"value":"371.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JPS63_401.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/6996/files/JPS63_401.pdf"},"version_id":"2b954818-ae60-418a-96fa-3841af5e8c4e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CGRP","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypersensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"Immobilization","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_scheme":"Other"},{"subitem_subject":"Spinal cord","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-19"},"publish_date":"2013-12-19","publish_status":"0","recid":"6996","relation_version_is_last":true,"title":["Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T02:34:11.625248+00:00"}